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Thomas R. Spitzer, MD

Professor, Department of Medicine, Harvard Medical School

Director, Bone Marrow Transplantation, Massachusetts General Hospital

Contact Info

Thomas Spitzer
Massachusetts General Hospital
55 Fruit St; 0 Emerson Place Suite 118
Boston, MA, 02114
Mailstop: Cox 640
Phone: 617-724-1124
Fax: 617-724-1126
TSpitzer@partners.org

Assistant

Not Available.

DF/HCC Program Affiliation

Cancer Immunology
Leukemia

Research Abstract

The primary focus of my research has been the development of novel strategies for performing HLA-mismatched donor bone marrow transplants and for separating the graft versus malignancy effects of transplantation from clinically significant graft versus host disease. A second aim has been to use bone marrow transplantation as a means of inducing tolerance for solid organ transplantation. We have recently developed a non-myeloablative transplant regimen in which mixed lymphohematopoietic chimerism is reliably induced. This mixed chimerism serves as a platform for subsequent adoptive cellular immunotherapy. Striking anti-tumor responses have been seen in the majority of patients with chemorefractory hematologic malignancies. This mixed chimerism has also been shown to induce donor specific allotolerance in one patient with multiple myeloma and end stage renal disease. Studies are underway to evaluate immunological reconstitution following these transplants, the specific contributions of donor and host cell populations to the multiple hematopoietic lineages, and to further define the potentially separable mechanisms of the graft versus host and graft versus malignancy responses.

Publications

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