DF/HCC Program Affiliation

DF/HCC Associations

Research Abstract

Publications

• Le X, Langenau DM, Keefe MD, Kutok JL, Neuberg DS, Zon LI.Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish.Proc Natl Acad Sci U S A 2007 May 21.
  17517602
• Shepard JL, Amatruda JF, Finkelstein D, Ziai J, Finley KR, Stern HM, Chiang K, Hersey C, Barut B, Freeman JL, Lee C, Glickman JN, Kutok JL, Aster JC, Zon LI.A mutation in separase causes genome instability and increased susceptibility to epithelial cancer
  17210788
• Koschmieder S, Goettgens B, Zhang P, Iwasaki-Arai J, Akashi K, Kutok JL, Dayaram T, Geary K, Green AR, Tenen DG, Huettner CS.Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogen
  15331442
• Sasaki Y, Casola S, Kutok JL, Rajewsky K, Schmidt-Supprian M.TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology.J Immunol 2004 Aug 15;173(4):2245-52.
  15294936
• Dimitroff CJ, Lechpammer M, Long-Woodward D, Kutok JL.Rolling of Human Bone-Metastatic Prostate Tumor Cells on Human Bone Marrow Endothelium under Shear Flow Is Mediated by E-Selectin.Cancer Res 2004 Aug 1;64(15):5261-9.
  15289332
• Araki T, Mohi MG, Ismat FA, Bronson RT, Williams IR, Kutok JL, Yang W, Pao LI, Gilliland DG, Epstein JA, Neel BG.Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation.Nat Med 2004 Aug;10(8):849-57.
  15273746
• Rivailler P, Carville A, Kaur A, Rao P, Quink C, Kutok JL, Westmoreland S, Klumpp S, Simon M, Aster JC, Wang F.Experimental Rhesus Lymphocryptovirus Infection in Immunosuppressed Macaques: An Animal Model for Epstein-Barr Virus Pathogenesis in the Immunos
  15150077
• Rosenbauer F, Wagner K, Kutok JL, Iwasaki H, Le Beau MM, Okuno Y, Akashi K, Fiering S, Tenen DG.Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.Nat Genet 2004 Jun;36(6):624-30.
  15146183
• Traver D, Winzeler A, Stern HM, Mayhall EA, Langenau DM, Kutok JL, Look AT, Zon LI.Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation.Blood 2004 Sep 1;104(5):1298-305.
  15142873
• Das I, Craig C, Funahashi Y, Jung KM, Kim TW, Byers R, Weng AP, Kutok JL, Aster JC, Kitajewski J.Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.J Biol Chem 2004 Jul 16;279(29):30771-80.
  15123653
• Langenau DM, Ferrando AA, Traver D, Kutok JL, Hezel JP, Kanki JP, Zon LI, Look AT, Trede NS.In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.Proc Natl Acad Sci U S A 2004 May 11;101(19):7369-74.
  15123839
• Brown JR, Gaudet G, Friedberg JW, Neuberg D, Mauch P, Kutok JL, Takvorian T, Fisher DC, Gribben JG, Kim H, Nadler LM, Freedman AS.Autologous bone marrow transplantation for marginal zone non-Hodgkin's lymphoma.Leuk Lymphoma 2004 Feb;45(2):315-20.
  15101717
• Manis JP, Morales JC, Xia Z, Kutok JL, Alt FW, Carpenter PB.53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.Nat Immunol 2004 May;5(5):481-7.
  15077110
• Chen J, Williams IR, Kutok JL, Duclos N, Anastasiadou E, Masters SC, Fu H, Gilliland DG.Positive and Negative Regulatory Roles of the WW-like Domain in TEL-PDGF{beta}R Transformation.Blood 2004 Mar 30.
  15054045
• Kutok JL, Klumpp S, Simon M, MacKey JJ, Nguyen V, Middeldorp JM, Aster JC, Wang F.Molecular evidence for rhesus lymphocryptovirus infection of epithelial cells in immunosuppressed rhesus macaques.J Virol 2004 Apr;78(7):3455-61.
  15016868
• Hsu K, Traver D, Kutok JL, Hagen A, Liu TX, Paw BH, Rhodes J, Berman JN, Zon LI, Kanki JP, Look AT.The pu.1 promoter drives myeloid gene expression in zebrafish.Blood 2004 Sep 1;104(5):1291-7.
  14996705
• Chan IT, Kutok JL, Williams IR, Cohen S, Kelly L, Shigematsu H, Johnson L, Akashi K, Tuveson DA, Jacks T, Gilliland DG.Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease.J Clin Invest 2004 Feb;113(4
  14966562
• Casola S, Otipoby KL, Alimzhanov M, Humme S, Uyttersprot N, Kutok JL, Carroll MC, Rajewsky K.B cell receptor signal strength determines B cell fate.Nat Immunol 2004 Mar;5(3):317-27.
  14758357
• Wu CJ, Hochberg EP, Rogers SA, Kutok JL, Biernacki M, Nascimento AF, Marks P, Bridges K, Ritz J.Molecular assessment of erythroid lineage chimerism following nonmyeloablative allogeneic stem cell transplantation.Exp Hematol 2003 Oct;31(10):924-33.
  14550808
• Kutok JL, Fletcher CD.Splenic vascular tumors.Semin Diagn Pathol 2003 May;20(2):128-39.
  12945936
• Savage KJ, Monti S, Kutok JL, Cattoretti G, Neuberg D, De Leval L, Kurtin P, Dal Cin P, Ladd C, Feuerhake F, Aguiar RC, Li S, Salles G, Berger F, Jing W, Pinkus GS, Habermann T, Dalla-Favera R, Harris NL, Aster JC, Golub TR, Shipp MA.The molecular signatu
  12933571
• Ranger AM, Zha J, Harada H, Datta SR, Danial NN, Gilmore AP, Kutok JL, Le Beau MM, Greenberg ME, Korsmeyer SJ.Bad-deficient mice develop diffuse large B cell lymphoma.Proc Natl Acad Sci U S A 2003 Aug 5;100(16):9324-9.
  12876200
• Lee BH, George S, Kutok JL.Langerhans cell histiocytosis involving the thymus. A case report and review of the literature.Arch Pathol Lab Med 2003 Jul;127(7):e294-7.
  12823060
• Cools J, Stover EH, Boulton CL, Gotlib J, Legare RD, Amaral SM, Curley DP, Duclos N, Rowan R, Kutok JL, Lee BH, Williams IR, Coutre SE, Stone RM, DeAngelo DJ, Marynen P, Manley PW, Meyer T, Fabbro D, Neuberg D, Weisberg E, Griffin JD, Gilliland DG.PKC412
  12781364
• Deguchi K, Ayton PM, Carapeti M, Kutok JL, Snyder CS, Williams IR, Cross NC, Glass CK, Cleary ML, Gilliland DG.MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP.Cancer Cell 2003 Mar;3(3)
  12676584
• Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA.The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.J Biol Chem 2003 Jun 13;278(24):21930-7.
  12670957
• Cools J, DeAngelo DJ, Gotlib J, Stover EH, Legare RD, Cortes J, Kutok J, Clark J, Galinsky I, Griffin JD, Cross NC, Tefferi A, Malone J, Alam R, Schrier SL, Schmid J, Rose M, Vandenberghe P, Verhoef G, Boogaerts M, Wlodarska I, Kantarjian H, Marynen P, Co
  12660384
• Schmollinger JC, Vonderheide RH, Hoar KM, Maecker B, Schultze JL, Hodi FS, Soiffer RJ, Jung K, Kuroda MJ, Letvin NL, Greenfield EA, Mihm M, Kutok JL, Dranoff G.Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruct
  12626761
• Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, Kanki JP, Lin S, Prochownik E, Trede NS, Zon LI, Look AT.Myc-induced T cell leukemia in transgenic zebrafish.Science 2003 Feb 7;299(5608):887-90.
  12574629
• Zinkel SS, Ong CC, Ferguson DO, Iwasaki H, Akashi K, Bronson RT, Kutok JL, Alt FW, Korsmeyer SJ.Proapoptotic BID is required for myeloid homeostasis and tumor suppression.Genes Dev 2003 Jan 15;17(2):229-39.
  12533511
• Husson H, Freedman AS, Cardoso AA, Schultze J, Munoz O, Strola G, Kutok J, Carideo EG, De Beaumont R, Caligaris-Cappio F, Ghia P.CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells.Br J Haematol 2002 Nov;
  12406091
• Kutok JL, Aster JC.Molecular biology of anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma.J Clin Oncol 2002 Sep 1;20(17):3691-702.
  12202671
• Hecht JL, Cibas ES, Kutok JL.Fine-needle aspiration cytology of lymphoproliferative disorders in the immunosuppressed patient: the diagnostic utility of in situ hybridization for Epstein-Barr virus.Diagn Cytopathol 2002 Jun;26(6):360-5.
  12112825
• Wohlschlegel JA, Kutok JL, Weng AP, Dutta A.Expression of geminin as a marker of cell proliferation in normal tissues and malignancies.Am J Pathol 2002 Jul;161(1):267-73.
  12107111
• Kelly LM, Kutok JL, Williams IR, Boulton CL, Amaral SM, Curley DP, Ley TJ, Gilliland DG.PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model.Proc Natl Acad Sci U S A 2002 Jun 11;99(12):8283-8.
  12060771
• Dash AB, Williams IR, Kutok JL, Tomasson MH, Anastasiadou E, Lindahl K, Li S, Van Etten RA, Borrow J, Housman D, Druker B, Gilliland DG.A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9.Proc Natl Acad Sci U S A 2002
  12032333
• Shipp MA, Ross KN, Tamayo P, Weng AP, Kutok JL, Aguiar RC, Gaasenbeek M, Angelo M, Reich M, Pinkus GS, Ray TS, Koval MA, Last KW, Norton A, Lister TA, Mesirov J, Neuberg DS, Lander ES, Aster JC, Golub TR.Diffuse large B-cell lymphoma outcome prediction by
  11786909
• Donato JL, Ko J, Kutok JL, Cheng T, Shirakawa T, Mao XQ, Beach D, Scadden DT, Sayegh MH, Adra CN.Human HTm4 is a hematopoietic cell cycle regulator.J Clin Invest 2002 Jan;109(1):51-8.
  11781350
• Kutok JL, Pinkus GS, Dorfman DM, Fletcher CD.Inflammatory pseudotumor of lymph node and spleen: an entity biologically distinct from inflammatory myofibroblastic tumor.Hum Pathol 2001 Dec;32(12):1382-7.
  11774173
• Kelly LM, Liu Q, Kutok JL, Williams IR, Boulton CL, Gilliland DG.FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model.Blood 2002 Jan 1;99(1):310
  11756186
• Schwaller J, Anastasiadou E, Cain D, Kutok J, Wojiski S, Williams IR, LaStarza R, Crescenzi B, Sternberg DW, Andreasson P, Schiavo R, Siena S, Mecucci C, Gilliland DG.H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to th
  11389034
• Frantsve J, Schwaller J, Sternberg DW, Kutok J, Gilliland DG.Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation.Mol Cell Biol 2001 May;21(10):
  11313480
• Tomasson MH, Williams IR, Li S, Kutok J, Cain D, Gillessen S, Dranoff G, Van Etten RA, Gilliland DG.Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or in
  11222391
• Liu Q, Schwaller J, Kutok J, Cain D, Aster JC, Williams IR, Gilliland DG.Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia.EMBO J 2000 Apr 17
  10775267