Robert C. Stanton, MD
Associate Professor, Department of Medicine, Harvard Medical School
Active Staff, Nephrology, Beth Israel Deaconess Medical Center
DF/HCC Program AffiliationKidney Cancer
My lab is focussed on the enzyme, glucose 6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentosephosphate pathway (PPP). The entire intracellular antioxidant system relies on G6PD to provide NADPH that is the principal intracellular reductant. In addition, G6PD can be prooxidant in that nitric oxide synthase and NADPH oxidase require NADPH . Traditionally it has been believed that G6PD and the PPP are constitutively active and under little regulation. Research from my lab has shown that G6PD is highly regulated both in its activity and intracellular location by signaling proteins such as PI 3- kinase. We have also shown that through its production of NADPH, G6PD plays critical roles in the regulation of cell growth and cell death (apoptosis). Thus we study how G6PD is regulated, the roles and importance of G6PD in cell growth and cell death, and whether specific diseases such as cancer are associated with alterations in G6PD.
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