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Tayyaba Hasan, PhD

Professor, Department of Dermatology, Harvard Medical School

Professor, Department of Health Sciences and Technology, Harvard Medical School

Biochemist, Wellman Center for Photomedicine, Massachusetts General Hospital

Contact Info

Tayyaba Hasan
Massachusetts General Hospital
40 Blossom Street
Boston, MA, 02114
Mailstop: BAR 314A
Phone: 617-726-6996
Fax: 617-724-1345
thasan@partners.org

Assistant

Bernadette Vijayakanthan
Administrative Coordinator
Dermatology
Massachusetts General Hospital
40 Blossom Street
BAR 314E
Boston, MA, 02114
Phone: 617-726-6856
Fax: 617-724-1345
bvijayakanthan@partners.org

DF/HCC Program Affiliation

Gynecologic Cancers

Research Abstract

Activation of certain chemicals with light leads to photochemical processes that involve the generation of free radicals and excited oxygen species. These molecular species are capable of destroying cells and tissues at or near the areas of photochemistry initiation. An advantage of this approach is that it provides the potential of double selectivity; first, due to the confinement of sites of illumination, and second, due to preferential localization of the activatable chemicals in many neoplastic tissues. Selectivity is further enhanced by delivering the photoactivatable molecules via vehicles such as antibodies and liposomes. The mechanisms of tissue destruction by photochemical processes are different from those used by most cheomtherapeutic drugs. This provides the possibility of using targeted photocemistry in combination with conventional chemotherapy to: 1) destroy cells that are resistant (acquired or intrinsic), and 2) achieve better (broader) tumor response due to the more varied arsenal for attack provided by the combination of photochemical and chemotherapeutic approaches. The best known biomedical application of photochemical targeting is photodynamic therapy (PDT). Research in our laboratories is focused on the mechanistic, therapeutic, and imaging aspects of photobiology to cancer.

Publications

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