DF/HCC Program Affiliation

Cancer Genetics
Breast Cancer
Gastrointestinal Malignancies

Research Abstract

Our laboratory at the Massachusetts General Hospital Cancer Center investigates the molecular and cellular basis of cancer progression in humans, with an eye towards translating findings into new diagnostic and treatment strategies. We use DNA, transcriptional, and proteomic profiling tools to generate genome-wide views of human cancer; emerging methods in stem cell biology and tissue engineering to experimentally model cancer progression in vitro and in vivo; genetic and chemical probes and advanced cellular imaging to functionally study identified genes and pathways; and computational biology and statistics for the in silico integration and analysis of this complex data stream. A major goal is to identify genes that are necessary for the survival of advanced tumors, to guide the development and clinical use of newer-generation cancer drugs and diagnostics.

Publications

• Ramaswamy S.Translating cancer genomics into clinical oncology.N Engl J Med 2004 Apr 29;350(18):1814-6.
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• Lamb J, Ramaswamy S, Ford HL, Contreras B, Martinez RV, Kittrell FS, Zahnow CA, Patterson N, Golub TR, Ewen ME.A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer.Cell 2003 Aug 8;114(3):323-34.
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• Ramaswamy S, Perou CM.DNA microarrays in breast cancer: the promise of personalised medicine.Lancet 2003 May 10;361(9369):1576-7.
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• Ramaswamy S, Ross KN, Lander ES, Golub TR.A molecular signature of metastasis in primary solid tumors.Nat Genet 2003 Jan;33(1):49-54.
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• Ramaswamy S, Golub TR.DNA microarrays in clinical oncology.J Clin Oncol 2002 Apr 1;20(7):1932-41.
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• Ramaswamy S, Tamayo P, Rifkin R, Mukherjee S, Yeang CH, Angelo M, Ladd C, Reich M, Latulippe E, Mesirov JP, Poggio T, Gerald W, Loda M, Lander ES, Golub TR.Multiclass cancer diagnosis using tumor gene expression signatures.Proc Natl Acad Sci U S A 2001 De
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