DF/HCC Program Affiliation

Cancer Immunology

Research Abstract

The major research interest of the Gabuzda lab is to understand molecular mechanisms of HIV replication and pathogenesis, and their implications for understanding pathogen-host interactions, immune responses, and disease outcomes. Using biological, genetic, biochemical, and systems biology approaches, we study: 1) HIV replication and pathogenesis in the immune system and central nervous system; 2) mechanisms and pathways underlying differences in host responses to viral infection and antiretroviral therapy; 3) viral diversity and tropism for specific cell types and tissues; 4) functions of the HIV Env, Vif, and Nef proteins; 5) high-throughput screening assays to identify small molecules that inhibit Vif interaction with its host cell cofactor APOBEC3G.

Publications

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