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Pamela M. McMahon, PhD

Assistant Professor, Department of Radiology, Harvard Medical School

Senior Scientist, Institute for Technology Assessment, Massachusetts General Hospital

Contact Info

Pamela McMahon
Massachusetts General Hospital
101 Merrimac St.

Boston, MA, 02114-4724
Phone not available.
Email not available

Assistant

Not Available.

DF/HCC Program Affiliation

Outcomes Research
Lung Cancer

Research Abstract

My research has focused on informing decisions about the appropriate use of imaging strategies for the diagnosis of cancer and other diseases.

I was a co-investigator on a project to develop a comprehensive Lung Cancer Policy Model (LCPM), (R01 CA97337, PI: Gazelle) to evaluate the cost-effectiveness of helical CT screening for lung cancer. The potentially enormous costs of a screening program and the large societal burden of disease from lung cancer are compelling reasons to evaluate the cost-effectiveness of screening protocols. Furthermore, imminent decisions on whether to screen for lung cancer will be made prior to the conclusions of ongoing trials; a model developed with existing information can help inform the debate. Results from the LCPM (in press and in preparation) suggest that screening asymptomatic current and former smokers could moderately decrease lung cancer mortality and lead to gains in life expectancy. We are currently evaluating the potential cost-effectiveness of lung cancer screening.

My current research involves developing approaches for modeling genomic and proteomic profiles in lung cancer; this work is funded by a National Cancer Institute Howard Temin Pathway to Independence (K99-R00) Award.

Other methodological research interests include Bayesian evidence synthesis, estimation of competing mortality risks, and calibration techniques for complex microsimulation models.

Publications

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