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Mary F. McNaughton-Collins, MD, MPH

Associate Professor, Department of Medicine, Harvard Medical School

Primary Care Physician, General Medicine Unit, Massachusetts General Hospital

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Mary McNaughton-Collins
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DF/HCC Program Affiliation

Outcomes Research
Prostate Cancer

Research Abstract

Dr. McNaughton Collins’ work focuses on outcomes research related to diseases of the prostate gland; prostate cancer, benign prostatic hyperplasia, and prostatitis. Her research emphasis at the interface of primary care and urology has been on men’s preferences and values regarding the outcomes of their care. For each of the three prostate conditions, she has studied the epidemiology, diagnosis, and treatment, as well as the health related quality of life impact. Methods employed have included analysis of the operating characteristics of diagnostic tests; development and validation of disease-specific health status measures; analysis of large, administrative databases; survey research; systematic literature reviews; and multi-institutional cohort studies and clinical trials. She is the Principal Investigator of the Harvard Clinical Center, which is one of 11 centers across North America involved in a series of treatment trials as part of the NIH/NIDDK-funded Chronic Prostatitis Collaborative Research Network (CPCRN). The first trial is underway, entitled “Randomized multicenter double-blind clinical trial to evaluate the efficacy and safety of 10mg Alfuzosin in the treatment of chronic prostatitis/chronic pelvic pain syndrome in recently-diagnosed and/or newly-symptomatic alpha-blocker naïve patients”. The second trial to begin enrolling soon is entitled “A randomized, placebo-controlled multicenter clinical trial to evaluate the efficacy and safety of Pregabalin for the treatment of chronic prostatitis/chronic pelvic pain syndrome”. Dr. McNaughton-Collins is also the Principal Investigator of a multi-center NIH/NIDDK-funded outcomes project “Chronic Urologic Pelvic Pain and Primary Care” where the goal is to understand the management of chronic urologic pelvic pain conditions, such as chronic prostatitis and interstitial cystitis, from the perspective of primary care providers, since most of what is known about these conditions has come solely from urology practices and tertiary care referral centers.


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