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Donald E. Ingber, MD, PhD

Judah Folkman Professor of Vascular Biology, Department of Pathology, Harvard Medical School

Research Associate, Pathology, Brigham And Women's Hospital

Research Associate, Vascular Biology Program, Boston Children's Hospital

Director, Executive Team, Wyss Institute for Biologically Inspired Engineering at Harvard Univ

Contact Info

Donald Ingber
Wyss Institute for Biologically Inspired Engineering at Harvard
3 Blackfan Circle

Boston, MA, 02115
Phone: 617-432-7044
Fax: 617-432-7828
don.ingber@wyss.harvard.edu

Assistant

Jeanne Nisbet
Assistant
Wyss Institute for Biologically Inspired Engineering at Harvard Univ
3 Blackfan Circle
CLSB, 5th floor
Boston, MA, 02115
Phone: 617-432-7041
Fax: 617-432-7828
jeanne.nisbet@childrens.harvard.edu

DF/HCC Program Affiliation

Angiogenesis, Invasion and Metastasis

Research Abstract

Dr. Ingber's research group focuses on the importance of extracellular matrix (ECM), integrins, and cytoskeletal structure for control of angiogenesis. They combine methods from diverse fields, including molecular cell biology, mechanical engineering, chemistry, and materials science, to address fundamental questions relating to the mechanism of capillary cell growth, differentiation, migration and apoptosis. Ingber was one of the first investigators to show that chemical modulators of ECM turnover can inhibit angiogenesis and induce capillary regression. His discovery also led to the development of the angiogenesisinhibitor, TNP-470, that is currently in human clinical trials.

Publications

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