Donald E. Ingber, MD, PhD

Judah Folkman Professor of Vascular Biology, Department of Pathology, Harvard Medical School

Research Associate, Pathology, Brigham And Women's Hospital

Research Associate, Vascular Biology Program, Children's Hospital Boston

Contact Info

Donald Ingber
Children's Hospital Boston
300 Longwood Avenue
Boston, MA, 02115
Mailstop: Karp 11.127
Phone: 617-919-2224
Fax: 617-730-0230
donald.ingber@childrens.harvard.edu

Assistant

Jeanne Nisbet
Assistant
Vascular Biology Program
Children's Hospital Boston
300 Longwood Avenue
Boston, MA, 02115
Mailstop: Karp Family Research Building
Phone: 617-919-2223
jeanne.nisbet@childrens.harvard.edu

DF/HCC Program Affiliation

Angiogenesis, Invasion and Metastasis

Research Abstract

Dr. Ingber's research group focuses on the importance of extracellular matrix (ECM), integrins, and cytoskeletal structure for control of angiogenesis. They combine methods from diverse fields, including molecular cell biology, mechanical engineering, chemistry, and materials science, to address fundamental questions relating to the mechanism of capillary cell growth, differentiation, migration and apoptosis. Ingber was one of the first investigators to show that chemical modulators of ECM turnover can inhibit angiogenesis and induce capillary regression. His discovery also led to the development of the angiogenesisinhibitor, TNP-470, that is currently in human clinical trials.

Publications

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DF/HCC Directory Login Update Member Profile Change Account Settings Applying for Membership Benefits Requirements Responsibilities	Donald E. Ingber, MD, PhD Judah Folkman Professor of Vascular Biology, Department of Pathology, Harvard Medical School Research Associate, Pathology, Brigham And Women's Hospital Research Associate, Vascular Biology Program, Children's Hospital Boston Contact Info Donald Ingber Children's Hospital Boston 300 Longwood Avenue Boston, MA, 02115 Mailstop: Karp 11.127 Phone: 617-919-2224 Fax: 617-730-0230 donald.ingber@childrens.harvard.edu Assistant Jeanne Nisbet Assistant Vascular Biology Program Children's Hospital Boston 300 Longwood Avenue Boston, MA, 02115 Mailstop: Karp Family Research Building Phone: 617-919-2223 jeanne.nisbet@childrens.harvard.edu DF/HCC Program Affiliation Angiogenesis, Invasion and Metastasis Research Abstract Dr. Ingber's research group focuses on the importance of extracellular matrix (ECM), integrins, and cytoskeletal structure for control of angiogenesis. They combine methods from diverse fields, including molecular cell biology, mechanical engineering, chemistry, and materials science, to address fundamental questions relating to the mechanism of capillary cell growth, differentiation, migration and apoptosis. Ingber was one of the first investigators to show that chemical modulators of ECM turnover can inhibit angiogenesis and induce capillary regression. His discovery also led to the development of the angiogenesisinhibitor, TNP-470, that is currently in human clinical trials. Publications View All Publications
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