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Donald E. Ingber, MD, PhD

Judah Folkman Professor of Vascular Biology, Department of Pathology, Harvard Medical School

Research Associate, Pathology, Brigham And Women's Hospital

Research Associate, Vascular Biology Program, Boston Children's Hospital

Director, Executive Team, Wyss Institute for Biologically Inspired Engineering at Harvard Univ

Contact Info

Donald Ingber
Boston Children's Hospital
300 Longwood Avenue
Boston, MA, 02115
Mailstop: Karp 11.127
Phone: 617-919-2224
Fax: 617-730-0230


Jeanne Nisbet
Vascular Biology Program
Boston Children's Hospital
300 Longwood Avenue
Boston, MA, 02115
Mailstop: Karp Family Research Building
Phone: 617-919-2223

DF/HCC Program Affiliation

Angiogenesis, Invasion and Metastasis

Research Abstract

Dr. Ingber's research group focuses on the importance of extracellular matrix (ECM), integrins, and cytoskeletal structure for control of angiogenesis. They combine methods from diverse fields, including molecular cell biology, mechanical engineering, chemistry, and materials science, to address fundamental questions relating to the mechanism of capillary cell growth, differentiation, migration and apoptosis. Ingber was one of the first investigators to show that chemical modulators of ECM turnover can inhibit angiogenesis and induce capillary regression. His discovery also led to the development of the angiogenesisinhibitor, TNP-470, that is currently in human clinical trials.


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