DF/HCC Program Affiliation

Breast Cancer

Research Abstract

My research interest focuses on the basic biology, pathology, and treatment of Breast cancer. My laboratory work focuses on the role of PI3K in breast cancer and the role of activating mutation in PI3K in breast cancer pathogenesis. I am also interested in translational research projects in breast cancer evaluating the clinical effect of alterations in the PI3K pathway. This interest also involves understanding the role of alterations in PI3K signaling on resistance to anti-tumour therapies. My clinical interest in the development of novel therapies for treating breast cancer through clinical trials.

Publications

• Haile RW, Thomas DC, McGuire V, Felberg A, John EM, Milne RL, Hopper JL, Jenkins MA, Levine AJ, Daly MM, Buys SS, Senie RT, Andrulis IL, Knight JA, Godwin AK, Southey M, McCredie MR, Giles GG, Andrews L, Tucker K, Miron A, Apicella C, Tesoriero A, Bane A,
  17021353
• Ganesan S, Richardson AL, Wang ZC, Iglehart JD, Miron A, Feunteun J, Silver D, Livingston DM.Abnormalities of the Inactive X Chromosome Are a Common Feature of BRCA1 Mutant and Sporadic Basal-like Breast Cancer.Cold Spring Harb Symp Quant Biol 2005;70:93-
  16869742
• Golshan M, Miron A, Nixon AJ, Garber JE, Cash EP, Iglehart JD, Harris JR, Wong JS.The prevalence of germline BRCA1 and BRCA2 mutations in young women with breast cancer undergoing breast-conservation therapy.Am J Surg 2006 Jul;192(1):58-62.
  16769276
• Richardson AL, Wang ZC, De Nicolo A, Lu X, Brown M, Miron A, Liao X, Iglehart JD, Livingston DM, Ganesan S.X chromosomal abnormalities in basal-like human breast cancer.Cancer Cell 2006 Feb;9(2):121-32.
  16473279