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S. J. Adelstein, MD, PhD

Paul C. Cabot Distinguished Professor of Medical Biophysics, Department of Radiology, Harvard Medical School

Senior Radiologist, Nuclear Medicine, Brigham And Women's Hospital

Professor, Nuclear Medicine, Brigham And Women's Hospital

Contact Info

S. Adelstein
Harvard Medical School
260 Longwood Avenue
Boston, MA, 02115
Mailstop: TMEC 145
Phone: 617-432-3997
Fax: 617-432-5717


Stephanie McHale
Harvard Medical School
Phone: 617-432-4152

DF/HCC Program Affiliation

Cancer Imaging

Research Abstract

Our laboratory studies the biophysical effects of densely ionizing radiation and its application to experimental cancer therapy. The interaction of alpha particles as well as Auger and Koster-Cronig electrons wtih chromosal DNA and its consituents is a central focus. Biological endpoints include double strand breaks, clonal survival, transformation and mutagenesis. The information obtained from these studies is used in the development of agents for targeted radionuclide therapy.We are also interested in cell surface enzymes and mitochondrial membranes as targets for radio-labeled imaging and therapeutic probes.


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