DF/HCC Program Affiliation

Cancer Genetics
Biostatistics

Lab Website

http://compbio.med.harvard.edu

Research Abstract

Dr. Park is interested in the development of computational methods for high-throughput genomic technologies and their application to the study of epigenetic mechanisms. These include identification of sites for protein-DNA binding, DNA methylation, and histone modification using chromatin immunoprecipitation on tiling microarrays (ChIP-chip) or sequencing (ChIP-seq), as well as detection of chromosomal aberrations using array comparative genomic hybridization (aCGH).

Publications

• Park PJ.Epigenetics meets next-generation sequencing.Epigenetics 2008 Nov;3(6):318-21.
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• Park PJ.Experimental design and data analysis for array comparative genomic hybridization.Cancer Invest 2008 Nov;26(9):923-8.
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• Kharchenko PV,Tolstorukov MY,Park PJ.Design and analysis of ChIP-seq experiments for DNA-binding proteins.Nat Biotechnol 2008 Dec;26(12):1351-9.
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• Alekseyenko AA,Peng S,Larschan E,Gorchakov AA,Lee OK,Kharchenko P,McGrath SD,Wang CI,Mardis ER,Park PJ,Kuroda MI.A sequence motif within chromatin entry sites directs MSL establishment on the Drosophila X chromosome.Cell 2008 Aug 22;134(4):599-609.
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• Kharchenko PV,Woo CJ,Tolstorukov MY,Kingston RE,Park PJ.Nucleosome positioning in human HOX gene clusters.Genome Res 2008 Oct;18(10):1554-61.
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• Orford K,Kharchenko P,Lai W,Dao MC,Worhunsky DJ,Ferro A,Janzen V,Park PJ,Scadden DT.Differential H3K4 methylation identifies developmentally poised hematopoietic genes.Dev Cell 2008 May;14(5):798-809.
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