DF/HCC Program Affiliation

Cancer Cell Biology

Research Abstract

Transcriptional regulation in response to environmental and developmental cues is mediated by the combinatorial and synergistic action of specific DNA-binding proteins on components of the general transcription machinery and on chromatin modifying activities. This laboratory combines genetic, molecular, and genomic approaches available in yeast and human cells to investigate a variety of issues. These include molecular mechanisms of transcriptional activation, relationship between chromatin structure of DNA and gene expression with particular emphasis epigenetic inheritance, and global transcriptional repression mechanisms mediated by corepressors that are recruited to specific genes. In addition, we are using genomic approaches to analyze transcriptional profiles and transcription factor occupancy during the transition of normal to transformed cells. Lastly, we are part of the ENCODE consortium to analyze genome-wide occupancy of transcription factors and chromatin-modifying activities in human cells.

Publications

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