DF/HCC Program Affiliation

Breast Cancer

Research Abstract

In her investigations of factors contributing to the development of osteoporosis, Dr. LeBoff has quantified bone mineral density and sensitive biochemical markers of bone turnover to investigate alterations in skeletal homeostasis associated with estrogen deficiency, low vitamin D levels, chemotherapy, organ transplantation, rheumatic diseases, and treatment with gonadotropin-releasing hormone agonists, and glucocorticoids.

In an NIH-sponsored prospective randomized, placebo controlled study, she is studying, with Dr. Charles Shapiro, skeletal turnover in women with breast cancer who develop chemotherapy-induced amenorrhea. Dr. LeBoff has an interest in chemotherapy-associated bone loss and strategies to prevent this bone loss.

Dr. LeBoff has been the principal investigator on a number of longitudinal, randomized studies evaluating the effects of hormone replacement therapy, nasal calcitonin, or third-generation bisphosphonates, 2 new selective estrogen receptor modulators on the prevention and/or treatment of osteoporosis. She is working on two NIH grants to understand the cellular and hormonal factors that underlie hip fractures.

Dr. LeBoff has been working on NIH grants to understand the cellular and hormonal factors that underlie hip fractures. Dr. LeBoff is the principal investigator on a new Department of Defense grant to study bone health in young women. Dr. LeBoff is also the Osteoporosis investigator at Brigham and Women's Hospital in the Women's Health Initiative (WHI) and on the Central Calcium and Vitamin D Committee for the WHI.

Publications

• Chen Z, Maricic M, Pettinger M, Ritenbaugh C, Lopez AM, Barad DH, Gass M, Leboff MS, Bassford TL.Osteoporosis and rate of bone loss among postmenopausal survivors of breast cancer.Cancer 2005 Oct 1;104(7):1520-30.
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• Shapiro CL, Phillips G, Van Poznak CH, Jackson R, Leboff MS, Woodard S, Lemeshow S.Baseline bone mineral density of the total lumbar spine may predict for chemotherapy-induced ovarian failure.Breast Cancer Res Treat 2005 Mar;90(1):41-6.
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• Chen Z, Maricic M, Bassford TL, Pettinger M, Ritenbaugh C, Lopez AM, Barad DH, Gass M, Leboff MS.Fracture risk among breast cancer survivors: results from the Women's Health Initiative Observational Study.Arch Intern Med 2005 Mar 14;165(5):552-8.
  15767532
• Shapiro CL, Keating J, Angell JE, Janicek M, Gelman R, Hayes D, LeBoff MS.Monitoring therapeutic response in skeletal metastases using dual-energy x-ray absorptiometry: a prospective feasibility study in breast cancer patients.Cancer Invest 1999;17(8):566
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• LeBoff MS, Kohlmeier L, Hurwitz S, Franklin J, Wright J, Glowacki J.Occult vitamin D deficiency in postmenopausal US women with acute hip fracture.JAMA 1999 Apr 28;281(16):1505-11.
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