DF/HCC Program Affiliation

Neuro-Oncology
Cancer Cell Biology

Research Abstract

Our research is directed towards understanding the mechanisms by which environmental stimuli including neurotrophins and neural activity elicit cellular responses in the developing and mature nervous system. Using mouse models and genome-wide screening technologies, our experiments have identified signal transduction pathways that mediate various processes during the development of the nervous system including cell fate determination and cell type specification, cell survival and death, axon and dendritic outgrowth, and synapse formation and refinement. As each of these steps is critical for the correct wiring and function of the mammalian brain, we are particularly interested in those proteins that, when mutated, lead to diseases such as cancer and disorders of cognitive function.

Publications

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