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Rakesh K. Jain, PhD

A. Werk Cook Professor of Radiation Oncology, Department of Radiation Oncology, Harvard Medical School

Director, Steele Laboratory, Massachusetts General Hospital

Contact Info

Rakesh Jain
Massachusetts General Hospital
100 Blossom Street
Boston, MA, 02114
Mailstop: Cox 7
Phone: 617-726-4083
Fax: 617-724-1819
jain@steele.mgh.harvard.edu

Assistant

Amy Jarvis
Administrative Assistant
Steele Laboratory
Massachusetts General Hospital
100 Blossom Street
Boston, MA, 02114
Phone: 617-726-4086
Fax: 617-724-1819
PAtoDrJain@steele.mgh.harvard.edu
Phyllis McNally
Administrative Assistant
Steele Laboratory
Massachusetts General Hospital
100 Blossom Street
Boston, MA, 02114
Phone: 617-726-8143
Fax: 617-724-5841
phyllis@steele.mgh.harvard.edu

DF/HCC Program Affiliation

Translational Pharmacology and Early Therapeutic Trials
Angiogenesis, Invasion and Metastasis
Breast Cancer

Research Abstract

The long term goal of our research is to understand the fundamental nature of vascular and interstitial barriers in human and rodent tumors, to overcome them or to exploit them for cancer detection and treatment. Quantitative understanding of pathophysiological phenomena in solid tumors is developed using five unique yet complementary approaches in our research: 1) a macroscopic approach using tissue-isolated tumors to monitor arterial and venous blood in rodent and human tumors; 2) a microscopic approach to directly visualize the events in the tumor microcirculation; 3) in vitro characterization of deformability, permeability, and adhesion of cells; 4) molecular biology techniques including development of transgenic cell lines and animals; and 5) mathematical modeling to integrate existing data and to guide new clinical and experimental studies. These five approaches are intertwined in six interdisciplinary projects: 1) tumor blood flow; 2) metabolic microenvironment; 3) transvascular transport; 4) interstitial transport; 5) cell transport; and 6) mathematical modeling.

Publications

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