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Eva C. Guinan, MD

Professor, Department of Radiation Oncology, Harvard Medical School

Director, Translational Research, Radiation Oncology, Dana-Farber Cancer Institute

Associate in Medicine, Hematology/Oncology, Boston Children's Hospital

Contact Info

Eva Guinan
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA, 02215
Mailstop: Mayer1B29
Phone: 617-632-4932
Fax: 617-632-3770
eva_guinan@dfci.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Cancer Immunology

Research Abstract

Our research laboratory focuses on two issues: 1)overcoming problems related to allogenicity in transplantation and 2) the role of endotoxin neutralization in mitigating the toxicity of radiotherapy.



In regard to the first, allogeneic transplantation is limited by immune attacks between donor and host. Global immunosuppression has been an incomplete and highly toxic approach to this problem. Current understanding of T cell activation suggests that blocking B7-CD28 interactions of the costimulatory pathway for human T helper cells provides an innovative way of producing antigen-specific T cell hyporesponsiveness and generation of regulatory T cells. We are applying these various strategies to the transplant setting.



In regard to the second area, we have found that a human endotoxin neutralizing molecule, bacteriacidal permeability increasing protein (BPI), has the capacity to dramatically decrease the side effects of radiation. We are pursing these observations both for emergency use (such as a nuclear accident) but also in terms of effects on chemoradiotherapy of cancer.

Publications

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