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Lee Josephson, PhD

Associate Professor, Department of Radiology, Harvard Medical School

Associate Professor, Center for Molecular Imaging Research, Massachusetts General Hospital

Contact Info

Lee Josephson
Massachusetts General Hospital
Building 149

Charlestown, MA, 02129
Mailstop: 5406
Phone: 617-726-6478
Fax: 617-726-5708
ljosephson@partners.org

Assistant

Not Available.

DF/HCC Program Affiliation

Cancer Imaging

Research Abstract

My research focuses on the design and uses of magnetic nanoparticles, near infrared fluorescent (NIRF), and magneto/optical probes for a wide range of questions in biology, chemistry and physics. I have developed nanoparticles that are detectable by MRI and NIRF (magneto/optical probes), and demonstrated their use as pre-operative MR contrast agents and intra-operative optical probes in important clinical applications including lymph node delineation and brain tumor delineation. A second area I am involved with is the development of annexin V based probes for imaging apoptosis, which plays a crucial in the pathology and treatment of disease. Annexin V is used to image the induction of apoptosis by chemotherapy, to predict long-term chemotherapeutic efficacy early in the course of treatment.

Publications

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