Lee Josephson, PhD
Associate Professor, Department of Radiology, Harvard Medical School
DF/HCC Program AffiliationCancer Imaging
My research focuses on the design and uses of magnetic nanoparticles, near infrared fluorescent (NIRF), and magneto/optical probes for a wide range of questions in biology, chemistry and physics. I have developed nanoparticles that are detectable by MRI and NIRF (magneto/optical probes), and demonstrated their use as pre-operative MR contrast agents and intra-operative optical probes in important clinical applications including lymph node delineation and brain tumor delineation. A second area I am involved with is the development of annexin V based probes for imaging apoptosis, which plays a crucial in the pathology and treatment of disease. Annexin V is used to image the induction of apoptosis by chemotherapy, to predict long-term chemotherapeutic efficacy early in the course of treatment.
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