DF/HCC Program Affiliation

Cancer Imaging

Research Abstract

My major research interests cover two main areas: in vivo MRI/MRS of human breast and prostate cancer and molecular imaging of human cancers. We have shown that the metabolic profile of human breast cancer is different and distinct from benign disease. We are involved in both developing technical improvements in in vivo MRS of breast disease and validating these methods in well defined clinical populations. Our efforts in human prostate cancer are aimed at the non-invasive determination of the agressiveness of the tumor based on its metabolic profile. We are also involved in technical improvements in the MRS methods as applied to the prostate. In the area of molecular imaging we are focusing on the developing MR contrast agents for the visualizing of malignant micro-calcifiactions in human breast disease. We have developed a novel animal model for micro-calcification in breast cancer.

Publications

• Sosna J, Pedrosa I, Dewolf WC, Mahallati H, Lenkinski RE, Rofsky NM.MR imaging of the prostate at 3 Tesla: comparison of an external phased-array coil to imaging with an endorectal coil at 1.5 Tesla.Acad Radiol 2004 Aug;11(8):857-62.
  15354305
• Bloch BN, Rofsky NM, Baroni RH, Marquis RP, Pedrosa I, Lenkinski RE.3 Tesla magnetic resonance imaging of the prostate with combined pelvic phased-array and endorectal coils; Initial experience(1).Acad Radiol 2004 Aug;11(8):863-7.
  15288036
• Lenkinski RE, Ahmed M, Zaheer A, Frangioni JV, Goldberg SN.Near-infrared fluorescence imaging of microcalcification in an animal model of breast cancer.Acad Radiol 2003 Oct;10(10):1159-64.
  14587634
• Zhang S, Merritt M, Woessner DE, Lenkinski RE, Sherry AD.PARACEST agents: modulating MRI contrast via water proton exchange.Acc Chem Res 2003 Oct;36(10):783-90.
  14567712
• Katz-Brull R, Lavin PT, Lenkinski RE.Clinical utility of proton magnetic resonance spectroscopy in characterizing breast lesions.J Natl Cancer Inst 2002 Aug 21;94(16):1197-203.
  12189222
• Zaheer A, Lenkinski RE, Mahmood A, Jones AG, Cantley LC, Frangioni JV.In vivo near-infrared fluorescence imaging of osteoblastic activity.Nat Biotechnol 2001 Dec;19(12):1148-54.
  11731784