DF/HCC Program Affiliation

Cancer Epidemiology

Research Abstract

My research interests include environmental and occupational exposures and gene-environment interactions as they relate to excess rates of cancers in farmers and agricultural workers. My colleagues and I are currently investigating the mutagenic and hormonal effects of exposure to triazine herbicides, which have been linked to aromatase induction in reptiles, and may be linked to ovarian cancer in women agricultural workers. We are evaluating whether triazine herbicide exposure affects Follicle Stimulating Hormone (FSH), Leutenizing Hormone (LH) and testosterone production. We are also evaluating whether the allelic variants in the CYP1A2 gene affects triazine metabolization and ultimately toxicity. Additionally I am interested in the design and evaluation of cancer preventive interventions to reduce hazardous exposures in occupational populations.

Publications

• Perry MJ, Chen X, Lu X.Automated scoring of multiprobe FISH in human spermatozoa.Cytometry A 2007 Sep 27;71A(11):968-972.
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• Perry MJ, Ouyang F, Korrick SA, Venners SA, Chen C, Xu X, Lasley BL, Wang X.A prospective study of serum DDT and progesterone and estrogen levels across the menstrual cycle in nulliparous women of reproductive age.Am J Epidemiol 2006 Dec 1;164(11):1056-64
  17023545
• Perry MJ, Venners SA, Barr DB, Xu X.Environmental pyrethroid and organophosphorus insecticide exposures and sperm concentration.Reprod Toxicol 2007 Jan;23(1):113-8.
  17011162
• Perry MJ, May JJ.Noise and Chemical Induced Hearing LossSpecial Considerations for Farm Youth.J Agromedicine 2005;10(2):49-55.
  16236671
• Perry MJ, Ouyang F, Korrick S, Venners SA, Altshul L, Xu X, Wang X.Body mass index and serum 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane in nulliparous Chinese women.Cancer Epidemiol Biomarkers Prev 2005 Oct;14(10):2433-8.
  16214928
• Venners SA, Korrick S, Xu X, Chen C, Guang W, Huang A, Altshul L, Perry M, Fu L, Wang X.Preconception serum DDT and pregnancy loss: a prospective study using a biomarker of pregnancy.Am J Epidemiol 2005 Oct 15;162(8):709-16.
  16120699
• Perry MJ, Layde PM.Farm pesticides: outcomes of a randomized controlled intervention to reduce risks.Am J Prev Med 2003 May;24(4):310-5.
  12726868
• Perry M, Christiani D, Dagenhart D, Tortorelli J, Singzoni B.Urinary biomarkers of atrazine exposure among farm pesticide applicators.Ann Epidemiol 2000 Oct 1;10(7):479.
  11018424