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Norman L. Letvin, MD

Professor, Department of Medicine, Harvard Medical School

Chief, Viral Pathogenesis, Beth Israel Deaconess Medical Center

Contact Info

Norman Letvin
Beth Israel Deaconess Medical Center
330 Brookline Avenue
Boston, MA, 02215
Mailstop: Research East Rm 113
Phone: 617-667-2766
Fax: 617-667-8210
nletvin@caregroup.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Cancer Immunology

Research Abstract

Dr. Letvin uses nonhuman primates for studying the immune response to AIDS virus infections. Dr. Letvin and his co-workers have defined an AIDS-like disease of monkeys, demonstrated that it is induced by the simian immunodeficiency virus (SIV), a close relative of the human AIDS virus, and have used this disease process as an animal model for the study of AIDS. They are also using it as a model for exploring vaccination strategies for protection against infection with the AIDS virus. In particular, they are assessing the use of plasmid DNA, live vector systems and peptide formulations to elicit AIDS virus-specific CTL. Dr. Letvin is also utilizing the SIV-induced disease of monkeys as a model for studying how cells of the immune system contain the spread of the AIDS virus in the infected individual. These studies have demonstrated the crucial role played by the CD8+ lymphocyte in controlling AIDS virus replication. Finally, he has utilized this disease in monkeys as a model system for examining novel therapeutic approaches to the treatment of AIDS.

Publications

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