DF/HCC Program Affiliation

Prostate Cancer
Cancer Genetics

Research Abstract

I am interested to determine if there are specific patterns of RNA expression in the blood that are predictive of different disease states. This is based on the Sentinel Principle in which the blood, which is in contact with all ofthe tissues, will be affected by alterations in the tissue. We have preliminary data to show that it is possible to differentiate between patients with prostate cancer from patients without cancer using this technique, and it is hoped with refinement to become a better predictor than serum PSA measurements. It may also be possible using this technique to develop a diagnostic test for colon and/or breast cancer

Publications

• Phimister AJ, Lango J, Lee EH, Ernst-Russell MA, Takeshima H, Ma J, Allen PD, Pessah IN.Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols.J Biol Chem 20
  17237236
• Yang T, Esteve E, Pessah IN, Molinski TF, Allen PD, Lopez JR.Elevated Resting [Ca2+]i in Myotubes Expressing Malignant Hyperthermia RyR1 cDNAs is Partially Restored by Modulation of Passive Calcium Leak from the Sarcoplasmic Reticulum.Am J Physiol Cell Ph
  17182726
• Sheridan DC, Takekura H, Franzini-Armstrong C, Beam KG, Allen PD, Perez CF.Bidirectional signaling between calcium channels of skeletal muscle requires multiple direct and indirect interactions.Proc Natl Acad Sci U S A 2006 Dec 26;103(52):19760-5.
  17172444
• Yang T, Riehl J, Esteve E, Matthaei KI, Goth S, Allen PD, Pessah IN, Lopez JR.Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse.Anesthesiology 2006 Dec;105(6):1164-75.
  17122579
• Lee EH, Song DW, Lee JM, Meissner G, Allen PD, Kim do H.Occurrence of atypical Ca2+ transients in triadin-binding deficient-RYR1 mutants.Biochem Biophys Res Commun 2006 Dec 29;351(4):909-14.
  17092484
• Moussa CE, Fu Q, Kumar P, Shtifman A, Lopez JR, Allen PD, LaFerla F, Weinberg D, Magrane J, Aprahamian T, Walsh K, Rosen KM, Querfurth HW.Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like patholo
  16940437
• Lee EH, Kim do H, Allen PD.Interplay between intra- and extracellular calcium ions.Mol Cells 2006 Jun 30;21(3):315-29.
  16819293
• Fessenden JD, Feng W, Pessah IN, Allen PD.Amino acid residues Gln4020 and Lys4021 of the ryanodine receptor type 1 are required for activation by 4-chloro-m-cresol.J Biol Chem 2006 May 31.
  16737973
• Samsó M, Shen X, Allen PD.Structural characterization of the RyR1-FKBP12 interaction.J Mol Biol 2006 Mar 3;356(4):917-27.
  16405911
• Hurne AM, O'brien JJ, Wingrove D, Cherednichenko G, Allen PD, Beam KG, Pessah IN.Ryanodine receptor type 1 (RyR1) mutations C4958S and C4961S reveal excitation-coupled calcium entry (ECCE) is independent of SR store depletion.J Biol Chem 2005 Aug 24.
  16120606
• Cunha-Neto E, Dzau VJ, Allen PD, Stamatiou D, Benvenutti L, Higuchi ML, Koyama NS, Silva JS, Kalil J, Liew CC.Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy.Am J Pathol 2005
  16049318
• Samsó M, Wagenknecht T, Allen PD.Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM.Nat Struct Mol Biol 2005 Jun;12(6):539-44.
  15908964
• Cherednichenko G, Hurne AM, Fessenden JD, Lee EH, Allen PD, Beam KG, Pessah IN.Conformational activation of Ca2+ entry by depolarization of skeletal myotubes.Proc Natl Acad Sci U S A 2004 Nov 2;101(44):15793-8.
  15505226
• Rivier F, Alkan O, Flint AF, Muskiewicz K, Allen PD, Leboulch P, Gussoni E.Role of bone marrow cell trafficking in replenishing skeletal muscle SP and MP cell populations.J Cell Sci 2004 Apr 15;117(Pt 10):1979-88.
  15054107
• Dos Remedios CG, Liew CC, Allen PD, Winslow RL, Van Eyk JE, Dunn MJ.Genomics, proteomics and bioinformatics of human heart failure.J Muscle Res Cell Motil 2003;24(4-6):251-60.
  14620738
• Perez CF, Mukherjee S, Allen PD.Amino acids 1-1,680 of ryanodine receptor type 1 hold critical determinants of skeletal type for excitation-contraction coupling. Role of divergence domain D2.J Biol Chem 2003 Oct 10;278(41):39644-52.
  12900411