DF/HCC Program Affiliation

Kidney Cancer

Research Abstract

My research focuses on the development and application of new MRI methods for noninvasive measurement of tissue function and pathology. A particular focus is the development of blood flow imaging methods. One technique of MRI blood flow imaging, arterial spin labeling, has shown particular promise for characterizing tumor vascular supply and its changes with tumor progression or antiangiogenic therapy. With recent NIH funding in this area, we will pursue the use of ASL blood flow MRI for tumor characterization and monitoring of renal cell carcinoma and glioma.

Publications

• de Bazelaire C, Rofsky NM, Duhamel G, Zhang J, Michaelson MD, George D, Alsop DC.Combined T2* and T1 measurements for improved perfusion and permeability studies in high field using dynamic contrast enhancement.Eur Radiol 2006 Apr 1.
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• Duhamel G, Schlaug G, Alsop DC.Measurement of arterial input functions for dynamic susceptibility contrast magnetic resonance imaging using echoplanar images: comparison of physical simulations with in vivo results.Magn Reson Med 2006 Mar;55(3):514-23.
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• Garcia DM, Duhamel G, Alsop DC.Efficiency of inversion pulses for background suppressed arterial spin labeling.Magn Reson Med 2005 Aug;54(2):366-72.
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• De Bazelaire C, Rofsky NM, Duhamel G, Michaelson MD, George D, Alsop DC.Arterial spin labeling blood flow magnetic resonance imaging for the characterization of metastatic renal cell carcinoma(1).Acad Radiol 2005 Mar;12(3):347-57.
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