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Shiv S. Pillai, PhD, MBBS

Professor, Department of Medicine, Harvard Medical School

Professor, Department of Health Sciences and Technology, Harvard Medical School

Contact Info

Shiv Pillai
Massachusetts General Hospital
Building 149

Charlestown, MA, 02129
Mailstop: MGH Cancer Center, Rm 7219
Phone: 617-726-5619
Fax: 617-724-9648


Not Available.

DF/HCC Program Affiliation

Cancer Immunology

Research Abstract

A major research interest is the study of cell fate decisions during B lymphocyte development. At different stages of B lymphocyte ontogeny membrane immunoglobulin associated signaling complexes select cells that have made in-frame rearrangements, commit cells to undergo programmed cell death, or provide signals for proliferation and differentiation. We wish to understand in detail the signals and pathways downstream of the pre-B and B cell receptors that commit cells to these distinct fates. The signaling pathways that we study are of relevance from the viewpoint of the malignant transformation of B cells.

A second area of interest is the examination of genetic susceptibility to cancer in terms of genes that influence the immune response. Studies are in progress on a large cohort of patients with breast cancer.


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