DF/HCC Program Affiliation

Cancer Immunology

Research Abstract

A major research interest is the study of cell fate decisions during B lymphocyte development. At different stages of B lymphocyte ontogeny membrane immunoglobulin associated signaling complexes select cells that have made in-frame rearrangements, commit cells to undergo programmed cell death, or provide signals for proliferation and differentiation. We wish to understand in detail the signals and pathways downstream of the pre-B and B cell receptors that commit cells to these distinct fates. The signaling pathways that we study are of relevance from the viewpoint of the malignant transformation of B cells.

A second area of interest is the examination of genetic susceptibility to cancer in terms of genes that influence the immune response. Studies are in progress on a large cohort of patients with breast cancer.

Publications

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