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William G. Kaelin, Jr., MD

Professor, Department of Medicine, Harvard Medical School

Senior Physician, Medicine, Brigham And Women's Hospital

Chair, Executive Committee for Research, Dana-Farber Cancer Institute

Contact Info

William Kaelin
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA, 02215
Mailstop: Mayer 457
Phone: 617-632-3975
Fax: 617-632-4760


Anne Madden
Medical Oncology
Dana-Farber Cancer Institute
Mailstop: MA457
Phone: 617-632-4747
Fax: 617-632-4760

DF/HCC Program Affiliation

Kidney Cancer, Co-Leader
Cancer Cell Biology

DF/HCC Associations

Member, Center Scientific Council
Associate Director, Basic Science, Executive Committee

Lab Website

Kaelin Laboratory Website

Research Abstract

The Kaelin Laboratory studies the functions of tumor suppressor proteins including the retinoblastoma protein (pRB), the von Hippel-Lindau protein (pVHL), and a homolog of the p53 tumor suppressor protein called p73. The laboratory uses a variety of molecular and cellular approaches to understand how, mechanistically, these proteins prevent tumor growth. One long term goal of this work is to lay the foundation for novel anticancer strategies. For example, one could envision the development of drugs that will selectively kill cells that lack a particular tumor suppressor protein or which will mimic a particular biochemical activity normally performed by a tumor suppressor protein.


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