DF/HCC Program Affiliation

Kidney Cancer, Co-Leader
Neuro-Oncology
Cancer Cell Biology

DF/HCC Associations

Associate Director, Basic Science, Executive Committee
Member, Center Scientific Council
Member, Web Advisory

Research Abstract

The Kaelin Laboratory studies the functions of tumor suppressor proteins including the retinoblastoma protein (pRB), the von Hippel-Lindau protein (pVHL), and a homolog of the p53 tumor suppressor protein called p73. The laboratory uses a variety of molecular and cellular approaches to understand how, mechanistically, these proteins prevent tumor growth. One long term goal of this work is to lay the foundation for novel anticancer strategies. For example, one could envision the development of drugs that will selectively kill cells that lack a particular tumor suppressor protein or which will mimic a particular biochemical activity normally performed by a tumor suppressor protein.

Publications

• Bommi-Reddy A, Almeciga I, Sawyer J, Geisen C, Li W, Harlow E, Kaelin WG, Grueneberg DA.Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen.Proc Natl Acad Sci U S A 2008 O
  18948595
• Kaelin WG.The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer.Nat Rev Cancer 2008 Nov;8(11):865-73.
  18923434
• Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT, Kaelin WG.Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.Blood 2008 Mar 15;111(6):3236-44.
  18096761
• Klose RJ, Yan Q, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG, Zhang Y, Kaelin WG.The retinoblastoma binding protein RBP2 is an H3K4 demethylase.Cell 2007 Mar 9;128(5):889-900.
  17320163
• Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG.HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.Science 2001 Apr 20;292(5516):464-8.
  11292862