DF/HCC Program Affiliation

Sarcoma
Cancer Genetics
Gastrointestinal Malignancies

Research Abstract

There are four areas of research focus in our laboratory. First is identification of novel therapeutic targets amongst the tyrosine kinase family of proteins. These efforts focus on sarcomas, mesothelioma, and other solid tumors. Second is discovery of oncogenic mechanisms and therapeutic targets in leiomyosarcoma, gastrointestinal stromal tumor, and mesothelioma. Third is use of molecular cytogenetic methods to identify novel oncogenes in solid tumors. Fourth is development of assays by which the best targeted therapy options can be determined for a given patient.

Publications

• Nucci MR, Drapkin R, Cin PD, Fletcher CD, Fletcher JA.Distinctive Cytogenetic Profile in Benign Metastasizing Leiomyoma: Pathogenetic Implications.Am J Surg Pathol 2007 May;31(5):737-743.
  17460458
• Zhu MJ, Ou WB, Fletcher CD, Cohen PS, Demetri GD, Fletcher JA.KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance.Oncogene 2007 Apr 23.
  17452978
• Chang BS, Yang T, Cibas ES, Fletcher JA.An in vitro cytologic assay for evaluation of the KIT signaling pathway in gastrointestinal stromal tumors.Mod Pathol 2007 May;20(5):579-83.
  17396139
• Liu Y, Tseng M, Perdreau SA, Rossi F, Antonescu C, Besmer P, Fletcher JA, Duensing S, Duensing A.Histone H2AX is a mediator of gastrointestinal stromal tumor cell apoptosis following treatment with imatinib mesylate.Cancer Res 2007 Mar 15;67(6):2685-92.
  17363589
• Fletcher JA, Rubin BP.KIT mutations in GIST.Curr Opin Genet Dev 2007 Feb;17(1):3-7.
  17208434
• Rezk S, Wheelock L, Fletcher JA, Oliveira AM, Keuker CP, Newburger PE, Xu B, Woda BA, Miron PM.Acute lymphocytic leukemia with eosinophilia and unusual karyotype.Leuk Lymphoma 2006 Jun;47(6):1176-9.
  16840218
• Duensing A, Joseph NE, Medeiros F, Smith F, Hornick JL, Heinrich MC, Corless CL, Demetri GD, Fletcher CD, Fletcher JA.Protein Kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs).Cancer Res 2004 Aug 1
  15289315
• Duensing A, Medeiros F, McConarty B, Joseph NE, Panigrahy D, Singer S, Fletcher CD, Demetri GD, Fletcher JA.Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs).Oncogene 2004 May 13;23(22):3999-4006.
  15007386
• French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA.BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma.Cancer Res 2003 Jan 15;63(2):304-7.
  12543779
• Heinrich MC, Corless CL, Duensing A, McGreevey L, Chen CJ, Joseph N, Singer S, Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CD, Fletcher JA.PDGFRA activating mutations in gastrointestinal stromal tumors.Science 2003 Jan 31;299(5607):708-10.
  12522257
• Kroll TG, Sarraf P, Pecciarini L, Chen CJ, Mueller E, Spiegelman BM, Fletcher JA.PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected].Science 2000 Aug 25;289(5483):1357-60.
  10958784