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Nir Hacohen, PhD

Associate Professor, Department of Medicine, Harvard Medical School

Immunologist, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital

Contact Info

Nir Hacohen
Massachusetts General Hospital
149 13th St
Charlestown, MA, 02129
Mailstop: 149-8410
Phone: 617-724-3768
Fax: 617-726-5651


Not Available.

DF/HCC Program Affiliation

Cancer Immunology

Research Abstract

Dr. Hacohen is an immunologist, geneticist and systems biologist focused on dissecting the basic mechanisms of immunity, developing and applying genetic technologies that accelerate the study of the immune system, and deciphering and treating human diseases -- including cancer and immune disorders -- based on genomic approaches. Dr. Hacohen is a founding member of the Broad Institute’s RNAi Consortium -- a public-private partnership that has built genome-wide RNA interference libraries to silence every gene in mice and humans -- and a founding director of the Broad Immune Circuits Initiative. These efforts have put RNAi technologies in the hands of the community to address numerous biological and immunological questions.

Projects in the laboratory focus on innate immunity and dendritic cells, as well as technology development, and include: (I) developing methods for network reconstruction of pathogen-sensing pathways in mice and humans, with a focus on viral and bacterial sensing pathways; (II) dissecting how DNA is sensed by the immune system, including the role of nucleases in clearance of self DNA; (III) analyzing mechanisms underlying autoimmunity in lupus patients; (IV) uncovering interactions between tumors and the immune system; (V) testing a new generation of personalized tumor vaccines (together with Dr. Catherine Wu, DFCI).


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