DF/HCC Program Affiliation

Breast Cancer
Cancer Immunology

Research Abstract

The evaluation of endogenous and inducible anti-tumor immunity is essential for vaccine development in solid tumors. My laboratory is examining the role of both antibody and cell-mediated immune responses to antigens overexpressed in breast cancer and other solid tumors, first identified by gene overexpression and later confirmed by protein overexpression in both pre-invasive and invasive cancers. We have also demonstrated that some proteins lead to autoantibody production by the immune system in a subset of patients. As a member of the Early Detection Research Network, we are using protein microarrays to identify autoantibodies in patients with early stage cancers, for potential biomarker development and to monitor immune responses to vaccine therapies.

Publications

• Shipitsin M, Campbell LL, Argani P, Weremowicz S, Bloushtain-Qimron N, Yao J, Nikolskaya T, Serebryiskaya T, Beroukhim R, Hu M, Halushka MK, Sukumar S, Parker LM, Anderson KS, Harris LN, Garber JE, Richardson AL, Schnitt SJ, Nikolsky Y, Gelman RS, Polyak
  17349583
• Weihrauch MR, Ansén S, Jurkiewicz E, Geisen C, Xia Z, Anderson KS, Gracien E, Schmidt M, Wittig B, Diehl V, Wolf J, Bohlen H, Nadler LM.Phase I/II combined chemoimmunotherapy with carcinoembryonic antigen-derived HLA-A2-restricted CAP-1 peptide and irinot
  16115944
• Anderson KS, LaBaer J.The sentinel within: exploiting the immune system for cancer biomarkers.J Proteome Res 2005 Jul-Aug;4(4):1123-33.
  16083262
• Maecker B, von Bergwelt-Baildon MS, Anderson KS, Vonderheide RH, Anderson KC, Nadler LM, Schultze JL.Rare naturally occurring immune responses to three epitopes from the widely expressed tumour antigens hTERT and CYP1B1 in multiple myeloma patients.Clin E
  16045747
• Vonderheide RH, Domchek SM, Schultze JL, George DJ, Hoar KM, Chen DY, Stephans KF, Masutomi K, Loda M, Xia Z, Anderson KS, Hahn WC, Nadler LM.Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes.Clin Cancer Res
  14871958
• Maecker B, Sherr DH, Vonderheide RH, von Bergwelt-Baildon MS, Hirano N, Anderson KS, Xia Z, Butler MO, Wucherpfennig KW, O'Hara C, Cole G, Kwak SS, Ramstedt U, Tomlinson AJ, Chicz RM, Nadler LM, Schultze JL.The shared tumor-associated antigen cytochrome P
  12869499
• Maecker B, Anderson KS, von Bergwelt-Baildon MS, Weller E, Vonderheide RH, Richardson PG, Schlossman RL, Menezes IA, Xia Z, Munshi NC, Anderson KC, Nadler LM, Schultze JL.Viral antigen-specific CD8+ T-cell responses are impaired in multiple myeloma.Br J H
  12786794
• von Bergwelt-Baildon MS, Vonderheide RH, Maecker B, Hirano N, Anderson KS, Butler MO, Xia Z, Zeng WY, Wucherpfennig KW, Nadler LM, Schultze JL.Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B c
  11964299
• Maecker B, von Bergwelt-Baildon , Anderson KS, Vonderheide RH, Schultze JL.Linking genomics to immunotherapy by reverse immunology--'immunomics' in the new millennium.Curr Mol Med 2001 Nov;1(5):609-19.
  11899235
• Vonderheide RH, Schultze JL, Anderson KS, Maecker B, Butler MO, Xia Z, Kuroda MJ, von Bergwelt-Baildon MS, Bedor MM, Hoar KM, Schnipper DR, Brooks MW, Letvin NL, Stephans KF, Wucherpfennig KW, Hahn WC, Nadler LM.Equivalent induction of telomerase-specific
  11731409
• Vonderheide RH, Anderson KS, Hahn WC, Butler MO, Schultze JL, Nadler LM.Characterization of HLA-A3-restricted cytotoxic T lymphocytes reactive against the widely expressed tumor antigen telomerase.Clin Cancer Res 2001 Nov;7(11):3343-8.
  11705846