DF/HCC Program Affiliation

Lymphoma and Myeloma, Co-Leader

DF/HCC Associations

Member, Center Scientific Council
Principal Investigator, Myeloma SPORE

Research Abstract

Our laboratory efforts focus on translational research in multiple myeloma. We characterize factors in the marrow microenvironment which allow tumor cell homing, growth and resistance to apoptosis in the marrow millieu in order to devise therapies which interrupt these processes. We are delineating signaling cascades mediating growth, death, and resistance to apoptosis in myeloma cells in order to devise novel treatment strategies which interrupt growth, trigger apoptosis, and overcome drug resistance. Finally, our efforts are directed to delinate mechanisms for enhancing allogeneic and autologous immunity to myeloma cells in order to derive related novel vaccincation and adoptive immunotherapy treatments.

Publications

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