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Rebecca D. Folkerth, MD

Associate Professor, Department of Pathology, Harvard Medical School

Associate Pathologist and Neuropathologist, Pathology, Brigham And Women's Hospital

Consultant, Pathology, Boston Children's Hospital

Contact Info

Rebecca Folkerth
Brigham And Women's Hospital
75 Francis Street
Boston, MA, 02115
Phone: 617-732-7532
Fax: 617-975-0944
rdfolkerth@bics.bwh.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Neuro-Oncology

Research Abstract

Among human tumors, gliomas have many distinctive and unique neuropathologic features. For example, vascular cells or endothelial proliferation is an indicator of anaplasia. Likewise, tumor neoangiogenesis results in characteristic neuroradiology enhancement and may be an eventual target of therapy. I have been involoved in collaborative work with Neuroradiologists and Neurosurgeons at the above institution in determining quantitative and qualitative measures of angiogenesis in adult and pediatric brain tumors, treated and untreated, and their relationship to prognosis and response to therapy; including experimental anti-angiogenic drugs; their relationship to secreted growth factors detectable in tissue and CSF; their correlation with proliferative indices; and their correlation with radiologic localization techniques, such as thallium technetium (SPECT) scanning.

A current investigation of thalidomide on measures of angiogenesis in central nervous system (CNS) tumors, of particular importance to the clinical trials of this drug, overseen by Dr. Howard Fine.

Publications

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