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Rosalind A. Segal, MD, PhD

Professor, Department of Neurobiology, Harvard Medical School

Professor of Neurobiology, Ted Williams Senior Investigator, Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute

Contact Info

Rosalind Segal
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA, 02215
Mailstop: Smith 1058
Phone: 617-632-4737
Fax: 617-632-2085
Rosalind_Segal@dfci.harvard.edu

Assistant

Michael Donohoe
Executive Assistant
Cancer Biology
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA, 02215
Mailstop: Smith 1036
Phone: 617-632-6488
Fax: 617-394-2819
michael_donohoe@dfci.harvard.edu

DF/HCC Program Affiliation

Cancer Cell Biology
Neuro-Oncology

Research Abstract

The research work in our laboratory has focused on growth factor signaling pathways that regulate survival, proliferation and migration in the developing vervous system. These pathways are normally exquisitely regulated; disruption of these pathways can result in brain tumors or neurodegenerative disorders.



Survival. During development, target derived neurotrophins promote the survival of presynapic cells, allowing neurons that are connected within a neural circuit to survive. Our studies investigate this long distance signaling and weather disruptions of these signals may cause ALS or other degenerative disorders.



Proliferation and migration. We have found that factors that contribute to the proliferation and migration of neural precursors in the developing brain also are responsible for the abnormal proliferation and migration of brain tumor cells. Our studies investigate how these processes are regulated in normal development, and how this regulation is lost in cancers.

Publications

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