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Rosalind A. Segal, MD, PhD

Professor, Department of Neurobiology, Harvard Medical School

Professor of Neurobiology, Ted Williams Senior Investigator, Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute

Contact Info

Rosalind Segal
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA, 02215
Mailstop: Smith 1058
Phone: 617-632-4737
Fax: 617-632-2085
Rosalind_Segal@dfci.harvard.edu

Assistant

Natalie Venay
Executive Assistant
Cancer Biology
Dana-Farber Cancer Institute
450 Brookline Avenue
Smith 1036
Boston, MA, 02115
Mailstop: SM1036
Phone: 617-632-6488
Fax: 617-632-4393
natalie_venay@dfci.harvard.edu

DF/HCC Program Affiliation

Cancer Cell Biology
Neuro-Oncology

Research Abstract

The research work in our laboratory has focused on growth factor signaling pathways that regulate survival, proliferation and migration in the developing nervous system. These pathways are normally exquisitely regulated; disruption of these pathways can result in brain tumors or neurodegenerative disorders.



Survival. During development, target derived neurotrophins promote the survival of presynapic cells, allowing neurons that are connected within a neural circuit to survive. Our studies investigate this long distance signaling. Our studies have identified a specialized gene expression program, the retrograde response genes, that prevent axonal degeneration. We use molecular imaging approacher to determine how transcripting and local ...of retrograde response genes are regulated.



Proliferation and migration. We have found that factors that contribute to the proliferation and migration of neural precursors in the developing brain also are responsible for the abnormal proliferation and migration of brain tumor cells. We have identified mechanisms whereby heparan sulgate proteoglycans and chemokines modulate SHH signaling and contribute to proliferation. Our studies focus on how these processes are regulated in normal development, and how this regulation is lost in cancers.

Publications

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