DF/HCC Program Affiliation

Cancer Cell Biology
Neuro-Oncology

Research Abstract

We are interested in the mechanism of Wnt signal transduction and its roles in early vertebrate development, in brain development and in human tumorigenesis. We are also interested in the signaling and transcriptional regulatory mechanism during vertebrate neural induction. We perform our studies in both the Xenopus embryo system and the mammalian cell culture system.

Publications

• Wei Q, Yokota C, Semenov MV, Doble B, Woodgett J, He X.R-spondin1 Is a High Affinity Ligand for LRP6 and Induces LRP6 Phosphorylation and beta-Catenin Signaling.J Biol Chem 2007 May 25;282(21):15903-11.
  17400545
• Yu A, Rual JF, Tamai K, Harada Y, Vidal M, He X, Kirchhausen T.Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling.Dev Cell 2007 Jan;12(1):129-41.
  17199046
• Semenov MV, He X.LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.J Biol Chem 2006 Dec 15;281(50):38276-84.
  17052975
• He X.Unwinding a path to nuclear beta-catenin.Cell 2006 Oct 6;127(1):40-2.
  17018273
• Li Y, Lu W, He X, Bu G.Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd.FEBS Lett 2006 Oct 2;580(22):5423-8.
  16989816
• Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan KL.TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulat
  16959574
• Yang J, Zhang W, Evans PM, Chen X, He X, Liu C.Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells.J Biol Chem 2006 Jun 30;281(26):17751-7.
  16798748
• Wu G, He X.Threonine 41 in beta-catenin serves as a key phosphorylation relay residue in beta-catenin degradation.Biochemistry 2006 Apr 25;45(16):5319-23.
  16618120
• Zhang W, Chen X, Kato Y, Evans PM, Yuan S, Yang J, Rychahou PG, Yang VW, He X, Evers BM, Liu C.Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression.Mol Cell Biol 2006 Mar;26(6):2055-64.
  16507986
• Habas R, He X.Activation of Rho and Rac by Wnt/frizzled signaling.Methods Enzymol 2006;406:500-11.
  16472682
• Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, Okamura H, Woodgett J, He X.A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation.Nature 2005 Dec 8;438(7069):873-7.
  16341017
• Kato Y, Shi Y, He X.Neuralization of the Xenopus embryo by inhibition of p300/ CREB-binding protein function.J Neurosci 1999 Nov 1;19(21):9364-73.
  10531441
• Liu C, Kato Y, Zhang Z, Do VM, Yankner BA, He X.beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation.Proc Natl Acad Sci U S A 1999 May 25;96(11):6273-8.
  10339577
• He X, Saint-Jeannet JP, Wang Y, Nathans J, Dawid I, Varmus H.A member of the Frizzled protein family mediating axis induction by Wnt-5A.Science 1997 Mar 14;275(5306):1652-4.
  9054360