DF/HCC Program Affiliation

Prostate Cancer

Research Abstract

My primary research focus is in vivo cancer detection. My laboratory is organized into three sections: 1) low-molecular weight ligand discovery, 2) contrast agent development and 3) imaging technology development. Working together, these sections form an integrated and organized effort to identify a clinical problem that can be solved by imaging, then to solve the problem by developing the appropriate contrast agents and detection technology. The long-term goal of this research is to detect the smallest possible number of malignant cells to guide cancer diagnosis, prognosis and therapy.

Publications

• Kim S, Lim YT, Soltesz EG, De Grand AM, Lee J, Nakayama A, Parker JA, Mihaljevic T, Laurence RG, Dor DM, Cohn LH, Bawendi MG, Frangioni JV.Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping.Nat Biotechnol 2004 Jan;22(1):93-7.
  14661026
• De Grand AM, Frangioni JV.An operational near-infrared fluorescence imaging system prototype for large animal surgery.Technol Cancer Res Treat 2003 Dec;2(6):553-62.
  14640766
• Lenkinski RE, Ahmed M, Zaheer A, Frangioni JV, Goldberg SN.Near-infrared fluorescence imaging of microcalcification in an animal model of breast cancer.Acad Radiol 2003 Oct;10(10):1159-64.
  14587634
• Frangioni JV.In vivo near-infrared fluorescence imaging.Curr Opin Chem Biol 2003 Oct;7(5):626-34.
  14580568
• Nakayama A, del Monte F, Hajjar RJ, Frangioni JV.Functional near-infrared fluorescence imaging for cardiac surgery and targeted gene therapy.Mol Imaging 2002 Oct;1(4):365-77.
  12940233