DF/HCC Program Affiliation

Gynecologic Cancer

Research Abstract

My primary research focus is epithelial ovarian cancer (EOC), the fifth leading cause of cancer-related mortality in women and the most lethal of all gynecologic tumors. I am using gene expression profiling to identify novel genes involved in malignant transformation and drug resistance, predict the outcome of advanced disease as well as response to novel therapies, and molecularly characterize a variety of EOC histologic subtypes. This involves a combination of data analysis as well as in vitro work with a special focus on elucidating platinum resistance as well as improving EOC prognostication.

Publications

• Burga LN,Tung NM,Troyan SL,Bostina M,Konstantinopoulos PA,Fountzilas H,Spentzos D,Miron A,Yassin YA,Lee BT,Wulf GM.Altered proliferation and differentiation properties of primary mammary epithelial cells from BRCA1 mutation carriers.Cancer Res 2009 Feb 15
  19190334
• Konstantinopoulos PA,Fountzilas E,Pillay K,Zerbini LF,Libermann TA,Cannistra SA,Spentzos D.Carboplatin-induced gene expression changes in vitro are prognostic of survival in epithelial ovarian cancer.BMC Med Genomics 2008;1:59.
  19038057
• Konstantinopoulos PA, Spentzos D, Cannistra SA.Gene-expression profiling in epithelial ovarian cancer.Nat Clin Pract Oncol 2008 Jul 22.
  18648354