Annarosa Leri, MD
Associate Professor, Department of Anesthesia, Harvard Medical School
Associate Professor, Anesthesiology, Brigham And Women's Hospital
DF/HCC Program AffiliationAngiogenesis, Invasion and Metastasis
The long-term objective of my research is to demonstrate that the heart is a self-renewing organ and, therefore, cardiac aging is determined by the progressive depletion of functionally competent cardiac stem cells. These studies investigate the mechanisms that control proliferation, senescence and death of undifferentiated cells. In particular, the regulation of telomerase-telomere axis (expression of telomerase, telomerase activity, telomere length) and p53 pathway is studied. In addition, our research aims at the control of migratory properties of primitive cells together with their engraftment and differentiation into parenchymal and vascular cells.
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