DF/HCC Program Affiliation

Prostate Cancer, Co-Leader
Cancer Immunology

DF/HCC Associations

Member, Center Scientific Council

Research Abstract

Dr. Sanda's research focuses on advancing and enhancing prostate cancer survival through investigations ranging from studies of prostate cancer associated antigens as targets of immune response or as markers for cancer detection, to clinical trials of novel therapy and observational outcomes research. He is the Principal Investigator of the PROST-QA Consortium, an NIH-funded clinical study evaluating patient-reported prostate cancer treatment outcomes that has enrolled over 2000 prostate cancer patients and spouses from 9 U.S. academic medical centers. He is Principal Investigator of the NIH U01-funded Harvard-Michigan Prostate Biomarker Clinical Center. He has helped spearhead two NCI Cooperative Group prostate cancer clinical trials, and he leads an NIH-funded laboratory investigating T cell responses and tolerance to prostate cancer-associated antigens in mouse models and human tissues, and the targeting of such antigens for cancer detection or therapy.

Publications

• Sokoll LJ, Wang Y, Feng Z, Kagan J, Partin AW, Sanda MG, Thompson IM, Chan DW.[-2]proenzyme prostate specific antigen for prostate cancer detection: a national cancer institute early detection research network validation study.J Urol 2008 Aug;180(2):539-4
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• Sanda MG, Dunn RL, Michalski J, Sandler HM, Northouse L, Hembroff L, Lin X, Greenfield TK, Litwin MS, Saigal CS, Mahadevan A, Klein E, Kibel A, Pisters LL, Kuban D, Kaplan I, Wood D, Ciezki J, Shah N, Wei JT.Quality of life and satisfaction with outcome a
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• Neeley YC, Arredouani MS, Hollenbeck B, Eng MH, Rubin MA, Sanda MG.Partially circumventing peripheral tolerance for oncogene-specific prostate cancer immunotherapy.Prostate 2008 Feb 26.
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• Tseng-Rogenski SS, Arredouani MS, Neeley YC, Lu B, Chinnaiyan AM, Sanda MG.Fas-mediated T cell deletion potentiates tumor antigen-specific tolerance in a mouse model of prostate cancer.Cancer Immunol Immunother 2008 Feb 12.
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