Bela Torok, PhD
Associate Professor, Department of Chemistry, University Of Massachusetts - Boston
Contact Info
Bela Torok
University of Massachusetts Boston
100 Morrissey Blvd
Boston, MA, 02125
Phone: 617-287-6159
bela.torok@umb.edu
Administrative Assistant
Chemistry
University Of Massachusetts - Boston
100 Morrissey Blvd.
Boston, MA, 02125
Phone: 617-287-6130
virginia.mackay@umb.edu
University of Massachusetts Boston
100 Morrissey Blvd
Boston, MA, 02125
Phone: 617-287-6159
bela.torok@umb.edu
Assistant
Virginia MacKayAdministrative Assistant
Chemistry
University Of Massachusetts - Boston
100 Morrissey Blvd.
Boston, MA, 02125
Phone: 617-287-6130
virginia.mackay@umb.edu
DF/HCC Program Affiliation
Translational Pharmacology and Early Therapeutic TrialsResearch Abstract
Development of synthetic methods for biologically active compounds.The first major focus area is the synthesis of heterocyclic compounds such as: benzo[N,N]-heterocycles (benzodiazepines, benzimidazoles, quinoxalines, quinoxalinones), phthalazinones, iso-benzofuranones. We have developed one step domino syntheses for the preparation of pyrazolines, pyrazoles, Hantzsch esters, and pyridines.
The second major area is the synthesis of organofluorine compounds. This topic includes a broad variety of molecules such as: trifluoromethyl-benzimidazoles, trifluoromethyl-Schiff-bases, trifluoromethyl-alpha-hydroxy-gamma-ketoesters, unnatural trifluormethyl-amino acids, 3,3,3-trifluoropropenes, alpha-fluoro-beta-trifluoromethyl-alpha, beta-unsaturated esters and indolyl-hydroxyl-trifluoromethyl-propionic acid esters.
Many in these groups of compounds have been earlier identified as potent anticancer agents.
