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Bela Torok, PhD

Associate Professor, Department of Chemistry, University Of Massachusetts - Boston

Contact Info

Bela Torok
University of Massachusetts Boston
100 Morrissey Blvd
Boston, MA, 02125
Phone: 617-287-6159
bela.torok@umb.edu

Assistant

Virginia MacKay
Administrative Assistant
Chemistry
University Of Massachusetts - Boston
100 Morrissey Blvd.
Boston, MA, 02125
Phone: 617-287-6130
virginia.mackay@umb.edu

DF/HCC Program Affiliation

Translational Pharmacology and Early Therapeutic Trials

Research Abstract

Development of synthetic methods for biologically active compounds.
The first major focus area is the synthesis of heterocyclic compounds such as: benzo[N,N]-heterocycles (benzodiazepines, benzimidazoles, quinoxalines, quinoxalinones), phthalazinones, iso-benzofuranones. We have developed one step domino syntheses for the preparation of pyrazolines, pyrazoles, Hantzsch esters, and pyridines.
The second major area is the synthesis of organofluorine compounds. This topic includes a broad variety of molecules such as: trifluoromethyl-benzimidazoles, trifluoromethyl-Schiff-bases, trifluoromethyl-alpha-hydroxy-gamma-ketoesters, unnatural trifluormethyl-amino acids, 3,3,3-trifluoropropenes, alpha-fluoro-beta-trifluoromethyl-alpha, beta-unsaturated esters and indolyl-hydroxyl-trifluoromethyl-propionic acid esters.
Many in these groups of compounds have been earlier identified as potent anticancer agents.

Publications

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