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Guocheng Yuan, PhD

Associate Professor, Department of Biostatistics, Harvard School Of Public Health

Associate Professor, Biostatistics and Computational Biology, Dana-Farber Cancer Institute

Contact Info

Guocheng Yuan
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA, 02215
Mailstop: CLS-11026
Phone: 617-582-8532
gcyuan@jimmy.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Biostatistics and Computational Biology

Lab Website

Yuan Lab

Research Abstract

We develop computational biology methodologies for genomic data analysis and integration, with the aim to understand systems-level gene regulatory mechanisms. Since virtually all the cells in a living organism share the same genome, epigenetic information provides an essential role in regulating cell-type specific gene expression patterns. Our long-term goal is to systematically investigate the structure and dynamics of the gene regulatory network and its role in maintenance of cell-type specificity. To this end, we have developed integrated approaches to identify the chromatin state organization, to determine the targeting mechanism for epigenetic factors, and to reconstruct the gene regulatory network from integration of multiple data-types. We have applied these approaches to stem cells and cancer biology. We actively participate in the ENCODE consortium. We collaborate closely with a number of basic scientists and clinical physicians at Harvard and affiliated hospitals.

Publications

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