DF/HCC Program Affiliation

Biostatistics and Computational Biology

Research Abstract

We develop statistical and computational methodologies for genomic data analysis and integration with the emphasis on epigenomics. We have developed algorithms to analyze tiling array data, thereby probing genome-scale chromatin structure at high resolutions. We have also developed computational methods to investigate how epigenetic factors are targeted toward specific genomic regions. A long term goal is to integrate epigenomic data together with gene expression, DNA sequence, transcription factor binding, and other genomic-scale information in order to understand the systems-level regulation of gene activities in stem cells and cancer tissues.

Publications

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