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Andrew S. Chi

Assistant Professor, Department of Neurology, Harvard Medical School

Research Associate, Molecular Pathology Unit and Center for Cancer Research , Massachusetts General Hospital

Research Associate, Cancer Program, Broad Institute of MIT and Harvard

Contact Info

Andrew Chi
Massachusetts General Hospital
55 Fruit St

Boston, MA, 02114
Mailstop: YAW 9E
Phone not available.
Email not available


Not Available.

DF/HCC Program Affiliation

Cancer Genetics

Research Abstract

‘Glioma stem cells’ are the most tumorigenic population of glioma cells and are thought to contribute to glioma initiation, maintenance, and resistance to therapy. When implanted as orthotopic xenografts, glioma stem cells form brain tumors that are histologically similar to the patient tumor from which the cells were derived. Therefore, these cells serve as excellent models for preclinical testing of potential malignant glioma therapies.

Our laboratory focuses on identifying molecular abnormalities in individual patient-derived glioma stem cell lines that may serve as predictive biomarkers for specific therapies. We molecularly characterize glioma stem cell lines using genetic and immunohistochemical methods and use these cell lines to screen targeted therapies in vitro and in vivo. We have generated a library consisting of over 40 patient-derived malignant glioma stem cell lines that form intracranial xenografts in immunocompromised mice, each with distict molecular features. These lines often retain molecular abnormalities identified in the patient tumors enabling us to test whether these naturally occuring cancer alterations impact sensitivity to specific therapies.


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