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Juan Melero-Martin

Assistant Professor, Department of Surgery, Harvard Medical School

Associate Scientific Research, Cardiac Surgery, Boston Children's Hospital

Contact Info

Juan Melero-Martin
Boston Children's Hospital
300 Longwood Ave.

Boston, MA, 02115
Phone: 617-919-3072
juan.meleromartin@childrens.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Angiogenesis, Invasion and Metastasis

Lab Website

Melero-Martin Lab

Research Abstract

The goal of my laboratory is to develop cell-based technologies that will allow engineering vascularized tissues in vivo using postnatal progenitor cells obtained from patients by non-invasive means. In particular, our focus is on the combined use of bone marrow-derived mesenchymal progenitor cells (MPCs) and human blood-derived endothelial progenitor cells (EPCs) to regenerate adipose and skeletal muscle tissues in vivo lost after tumor resections (e.g., mastectomy and carcinoma removal). The research conducted in my laboratory is trying to address whether generating a vascular implants with highly purified and defined MPCs and EPCs will drive tissue development in vivo. We give priority to the initial establishment of a functional vascular network within the implant, and propose that as a result of this neo-vascularization appropriate tissue formation and remodeling will be achieved.

Publications

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