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Paul L. Nguyen, MD

Associate Professor, Department of Radiation Oncology, Harvard Medical School

Director of Prostate Brachytherapy and Clinical Trials for Genitourinary Radiation Oncology, Radiation Oncology, Dana-Farber Cancer Institute

Contact Info

Paul Nguyen
Brigham and Women's Hospital
75 Francis Street

Boston, MA, 02115
Mailstop: ASB1- L2
Phone: 617-732-7936
Fax: 617-975-0912


Sharon Koogler
Radiation Oncology
Brigham And Women's Hospital
75 Francis Street
Boston, MA, 02115
Phone: 617-732-7936
Fax: 617-975-0912

DF/HCC Program Affiliation

Prostate Cancer

Research Abstract

My clinical and research focus is personalizing treatment for men with prostate cancer and optimizing their outcomes. The major areas of focus include:

1) Optimizing the use of androgen deprivation therapy (ADT) with radiation: This work includes understanding which patients are most likely vs. least likely to benefit from ADT, understanding the mechanisms by which ADT may be causing harm, and developing ways to minimize those harms.

2) Translational/Genetic Research: Using archived prostate tissue at the DFCI/BWH and colleagues at the Harvard School of Public Health, we are identifying biomarkers for prostate cancer recurrence and molecular pathways that can potentially be targeted to minimize the risk of recurrence.

3) Technical Innovations in the Delivery of Radiation: Working with collaborators in physics, radiology, and outside collaborators in engineering, we seek to reduce the side-effects of prostate brachytherapy by using additional imaging and novel devices to decrease the dose delivered to the urethra and rectum.


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