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Winston Patrick Kuo, DDS, DMSc

Assistant Professor, Department of Developmental Biology, Harvard School Of Dental Medicine

Director, Harvard Catalyst - LITT, Harvard Medical School

Contact Info

Winston Kuo
Harvard Medical School
Harvard Catalyst - LITT

Boston, MA, 02115
Phone: 617-432-1894
wkuo@genetics.med.harvard.edu

Assistant

Gary Smejkal
Research Assistant
Harvard Catalyst - LITT
Harvard Medical School
New Research Building, 77 Avenue Louis Pasteur
Section 358 Bays 7 & 6
Boston, MA, 02115
Phone: 617-432-5971
gary_smejkal@hms.harvard.edu
Alex Trachtenberg
Research Assistant
Harvard Catalyst - LITT
Harvard Medical School
New Research Building, 77 Avenue Louis Pasteur
Section 358 Bays 7 & 6
Boston, MA, 02115
Phone: 617-432-5971
Alexander_Trachtenberg@hms.harvard.edu

DF/HCC Program Affiliation

Head and Neck Cancer
Angiogenesis, Invasion and Metastasis

Lab Website

HC-LITT

Research Abstract

Our study of oral cancer involves the mining and analysis of data for a panel of biomarkers that will allow for the identification of molecularly premalignant lesions as well histologic dysplastic lesions that are more likely to progress to cancer. Such identification would be of great value as early detection has the greatest impact on survival for oral cancer. Accordingly, gene expression profiling of microdissected keratinocytes from biopsies containing normal mucosal tissue and invasive HNSCC will be performed to define a set of genes with marked alteration in expression in the course of carcinogenic transformation. These potential markers will then be subjected to a two-step validation process to determine their potential utility as biomarkers for two distinct phases of cancer progression.

Publications

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