Winston Patrick Kuo, DDS, DMSc
Assistant Professor, Department of Developmental Biology, Harvard School Of Dental Medicine
Director, Harvard Catalyst - LITT, Harvard Medical School
DF/HCC Program AffiliationHead and Neck CancerAngiogenesis, Invasion and Metastasis
Our study of oral cancer involves the mining and analysis of data for a panel of biomarkers that will allow for the identification of molecularly premalignant lesions as well histologic dysplastic lesions that are more likely to progress to cancer. Such identification would be of great value as early detection has the greatest impact on survival for oral cancer. Accordingly, gene expression profiling of microdissected keratinocytes from biopsies containing normal mucosal tissue and invasive HNSCC will be performed to define a set of genes with marked alteration in expression in the course of carcinogenic transformation. These potential markers will then be subjected to a two-step validation process to determine their potential utility as biomarkers for two distinct phases of cancer progression.
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