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David T. Breault, MD, PhD

Assistant Professor, Department of Pediatrics, Harvard Medical School

Associate, Medicine, Boston Children's Hospital

Contact Info

David Breault
Boston Children's Hospital
Division of Endocrinology

Boston, MA, 02115
Mailstop: CLS 16026
Phone: 617-919-2863
Fax: 617-730-0244
david.breault@childrens.harvard.edu

Assistant

Camilla Richmond
Fellow in Gastroenterology
Boston Children's Hospital
Phone: 617-919-2876
camilla.richmond@childrens.harvard.edu
Kelly Feeley
Administrative Associate
Boston Children's Hospital
Phone: 617-919-2930
kelly.feeley@childrens.harvard.edu

DF/HCC Program Affiliation

Gastrointestinal Malignancies

Research Abstract

We are pursuing the hypothesis that slowly cycling and rapidly cycling intestinal stem cells exhibit distinctly different responses to tumor initiating signals. Preliminary results indicate that adenoma formation does not arise from slowly cycling (quiescent) stem cells. Ongoing work is focused on defining the mechanism underlying this tumor suppressor state, including analysis of gene expression and microRNA signatures.
Comparative analysis of rapidly and slowly cycling stem cells will provide unique insight into the mechanisms regulating the initial steps of cancer initiation.

Publications

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