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Andrius Kazlauskas, PhD

Professor, Department of Ophthalmology, Harvard Medical School

Senior Scientist, SERI, Schepens Eye Research Institute

Contact Info

Andrius Kazlauskas
Schepens Eye Research Institute
20 Staniford Street
Boston, MA, 02114
Phone: 617-912-2517
Fax: 617-912-0101
ak@eri.harvard.edu

Assistant

Karen Jarvis
Administrative Assistant
Schepens Opthalmology
Schepens Eye Research Institute
20 Staniford Street
Boston, MA, 02114
Phone: 617-912-2568
Fax: 617-912-0101
vision.training@schepens.harvard.edu

DF/HCC Program Affiliation

Angiogenesis, Invasion and Metastasis

Research Abstract

Our long-term goal is to define signaling pathways that promote regression of vessels. Recognizing that an integral part of the angiogenic program is vessel destabilization and regression, we hypothesized that there is a naturally occurring signaling system directing this response. Indeed, we discovered that while certain signaling enzymes (such as phosphoinositide 3 kinase and Akt) promote vessel formation, others (such as phospholipase C γ [PLCγ]) induce both destabilization and regression of vessels. We are currently focusing on the mechanism by which PLCγ destabilizes vessels, and the application of these findings to both in vivo and clinical settings.

Publications

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