DF/HCC Program Affiliation

Angiogenesis, Invasion, and Metastasis

Research Abstract

My research focuses on understanding the mechanisms of organotropism of human cancers, which is driven from molecular target discovery and target validation approaches. I am currently investigating human prostate tumor cell adhesion molecules that initiate attachment to bone marrow endothelium under blood flow conditions. Since these adhesive attachments are principally mediated by tumor cell glycoconjugates, I have also been actively involved in the structural and biochemical characterization of the critical carbohydrate determinants, which bind their cognate receptor(s) on microvascular endothelium. In addition, I am developing carbohydrate-based compounds that have been designed to interfere with the expression and function of these tumor cell glycoconjugates with the intention of validating the putative role of these carbohydrates in metastatic phenotype and of suppressing metastatic potential.

Publications

• Descheny L, Gainers ME, Walcheck B, Dimitroff CJ.Ameliorating skin-homing receptors on malignant T cells with a fluorosugar analog of N-acetylglucosamine: P-selectin ligand is a more sensitive target than E-selectin ligand.J Invest Dermatol 2006 Sep;126(9
  16691194
• Dimitroff CJ, Descheny L, Trujillo N, Kim R, Nguyen V, Huang W, Pienta KJ, Kutok JL, Rubin MA.Identification of leukocyte E-selectin ligands, P-selectin glycoprotein ligand-1 and E-selectin ligand-1, on human metastatic prostate tumor cells.Cancer Res 200
  15994950
• Dimitroff CJ, Lechpammer M, Long-Woodward D, Kutok JL.Rolling of Human Bone-Metastatic Prostate Tumor Cells on Human Bone Marrow Endothelium under Shear Flow Is Mediated by E-Selectin.Cancer Res 2004 Aug 1;64(15):5261-9.
  15289332
• Dimitroff CJ, Kupper TS, Sackstein R.Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen.J Clin Invest 2003 Oct;112(7):1008-18.
  14523038
• Dimitroff CJ, Bernacki RJ, Sackstein R.Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin.Blood 2003 Jan 15;101(2):602-10.
  12393521
• Fuhlbrigge RC, King SL, Dimitroff CJ, Kupper TS, Sackstein R.Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots.J Immunol 2002 Jun 1;168(11):5645-51.
  12023362
• Dimitroff CJ, Lee JY, Fuhlbrigge RC, Sackstein R.A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells.Proc Natl Acad Sci U S A 2000 Dec 5;97(25):13841-6.
  11095749
• Sackstein R, Dimitroff CJ.A hematopoietic cell L-selectin ligand that is distinct from PSGL-1 and displays N-glycan-dependent binding activity.Blood 2000 Oct 15;96(8):2765-74.
  11023510