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Charles J. Dimitroff, PhD

Assistant Professor, Department of Dermatology, Harvard Medical School

Assistant Professor, Dermatology, Brigham And Women's Hospital

Contact Info

Charles Dimitroff
Brigham and Women's Hospital
77 Avenue Louis Pasteur
Boston, MA, 02115
Mailstop: HIM, Rm.650
Phone: 617-525-5693
Fax: 617-525-5571
cdimitroff@rics.bwh.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Angiogenesis, Invasion and Metastasis

Research Abstract

My research focuses on understanding the mechanisms of organotropism of human cancers, which is driven from molecular target discovery and target validation approaches. I am currently investigating human prostate tumor cell adhesion molecules that initiate attachment to bone marrow endothelium under blood flow conditions. Since these adhesive attachments are principally mediated by tumor cell glycoconjugates, I have also been actively involved in the structural and biochemical characterization of the critical carbohydrate determinants, which bind their cognate receptor(s) on microvascular endothelium. In addition, I am developing carbohydrate-based compounds that have been designed to interfere with the expression and function of these tumor cell glycoconjugates with the intention of validating the putative role of these carbohydrates in metastatic phenotype and of suppressing metastatic potential.

Publications

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