Charles J. Dimitroff, PhD
Assistant Professor, Department of Dermatology, Harvard Medical School
Assistant Professor, Dermatology, Brigham And Women's Hospital
DF/HCC Program AffiliationAngiogenesis, Invasion and Metastasis
My research focuses on understanding the mechanisms of organotropism of human cancers, which is driven from molecular target discovery and target validation approaches. I am currently investigating human prostate tumor cell adhesion molecules that initiate attachment to bone marrow endothelium under blood flow conditions. Since these adhesive attachments are principally mediated by tumor cell glycoconjugates, I have also been actively involved in the structural and biochemical characterization of the critical carbohydrate determinants, which bind their cognate receptor(s) on microvascular endothelium. In addition, I am developing carbohydrate-based compounds that have been designed to interfere with the expression and function of these tumor cell glycoconjugates with the intention of validating the putative role of these carbohydrates in metastatic phenotype and of suppressing metastatic potential.
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