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Charles J. Dimitroff, PhD

Associate Professor, Department of Dermatology, Harvard Medical School

Associate Professor, Dermatology, Brigham And Women's Hospital

Contact Info

Charles Dimitroff
Brigham and Women's Hospital
77 Avenue Louis Pasteur
Boston, MA, 02115
Mailstop: HIM, Rm.650
Phone: 617-525-5693
Fax: 617-525-5571
cdimitroff@rics.bwh.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Angiogenesis, Invasion and Metastasis

Research Abstract

My research focuses on understanding the origin and progression of human cancers. This goal is driven from molecular target discovery and target validation approaches. I am currently investigating 1.) how immune cells respond to tumor-derived factors through carbohydrate-dependent mechanisms and 2.) how cell surface carbohydrates on tumor cells can be used to predict tumorigenicity and metastatic progression. We conduct structural and biochemical characterization of the critical carbohydrate determinants on immune/host cells or tumor cells. Results from these studies provide new insights on how tumors become malignant, grow and form distant metastases and how tumors evade host immune responses.

Publications

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