DF/HCC Program Affiliation

Neuro-Oncology

Lab Website

http://www.childrenshospital.org/cfapps/research/data_admin/Site598/mainpageS598P0.html

Research Abstract

Correct positioning of neurons is achieved by directed neuronal migration whose failure results in various neurological disorders. Our research is focused on understanding how the neurons acquire the positioning cues during cerebral cortical development. Using biochemical and proteomic approaches and various mouse models, we have identified a novel pair of receptor-ligand that mediates the cross talk between the meninges and pial basement membrane and neuronal migration. Further work is designed to elucidating the signaling pathways that is crucial in brain development and malformation.

Publications

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