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Kathryn D. Held, PhD

Associate Professor, Department of Radiation Oncology, Harvard Medical School

Associate Radiation Biologist, Radiation Oncology, Massachusetts General Hospital

Contact Info

Kathryn Held
Massachusetts General Hospital
55 Fruit Street
Boston, MA, 02114
Mailstop: Cox 302
Phone: 617-726-8161
Fax: 617-724-8320
kheld@partners.org

Assistant

Not Available.

DF/HCC Program Affiliation

Cancer Cell Biology
Breast Cancer

Research Abstract

Our research covers two related areas: cellular responses to localized oxidative stress and mechanisms for stress-induced bystander effects. The studies on localized oxidative stress involve a team approach for use of state-of-the-art methods such as ionizing radiation microbeams, in collaboration with a group in the UK, and subcellularly localized photosensitizers to study biochemical pathways involved in triggering of apoptosis, mutagenesis, and DNA damage and repair after subcellularly localized stress induction, e.g., in nuclear versus non-nuclear regions including plasma membranes and mitochondria. Cells containing genetic mutations or knock-downs in apoptosis and DNA repair pathways are used, and cellular responses are followed, among other approaches, by use of sophisticated time-lapse microscopy. The studies on stress-induced bystander effects involve investigation of the signaling pathways whereby a cell that is damaged by ionizing radiation, photosensitizers or other oxidative stresses sends a signal to neighboring undamaged cells which then show a biological response. These studies include use of a unique heavy ion irradiation facility at Brookhaven National Laboratory.

Publications

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