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Benjamin D. Humphreys, MD, PhD

Associate Professor, Department of Medicine, Harvard Medical School

Director, Onco-Nephrology Program, Dana-Farber Cancer Institute

Associate Physician, Medicine, Brigham And Women's Hospital

Contact Info

Benjamin Humphreys
Brigham and Women's Hospital
Harvard Institutes of Medicine Rm 534 4 Blackfan Circle

Boston, MA, 02115
Phone: 617-525-5971
Fax: 617-525-5965
bhumphreys@partners.org

Assistant

Not Available.

DF/HCC Program Affiliation

Sarcoma
Translational Pharmacology and Early Therapeutic Trials

Lab Website

Humphreys Lab

Research Abstract

In my translational research laboratory I investigate the mechanisms of kidney injury and repair. Our mission is to understand the cellular and molecular mechanisms of this process in order to identify new therapeutic strategies for humans suffering from kidney disease. One particular focus is the role of the hedgehog signaling pathway in kidney homeostasis and injury. In separate studies, we use genetic lineage analysis and RNA-sequencing approaches to define cellular hierarchies and catalog gene expression changes in individual cell types during kidney injury. We use in vitro approaches, mouse genetic models and human studies. My clinical specialty is Onco-Nephrology - kidney disease associated with cancer and its treatment, and I investigate the mechanisms of targeted therapy-induced kidney toxicity in humans, including hypertension and proteinuria.

Publications

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