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Joanna Yeh, PhD

Assistant Professor, Department of Medicine, Harvard Medical School

Assistant Biologist, Cardiology, Massachusetts General Hospital

Contact Info

Jing-Ruey Yeh
Massachusetts General Hospital
149 13th St

Charlestown, MA, 02129
Mailstop: 149-4201
Phone: 617-643-3580
Fax: 617-726-5806
jyeh1@partners.org

Assistant

Not Available.

DF/HCC Program Affiliation

Leukemia
Angiogenesis, Invasion and Metastasis

Lab Website

Yeh faculty website

Research Abstract

The Yeh lab is specialized in chemical biology and disease modeling using cell culture, mice and zebrafish. In addition, we are working at the forefront of genome engineering using zinc finger nuclease (ZFN), TALE nuclease and CRISPR-Cas technologies. Through a chemical screen in zebrafish, we have previously identified that cyclooxygenase-2 (COX-2) inhibitors can suppress the leukemia stem cells expressing the AML1-ETO oncogene. Based on this finding, the plan to conduct a clinical trial of a COX inhibitor in patients with acute myeloid leukemia (AML) is underway. Currently, Dr. Yeh’s laboratory is also investigating the metabolic pathways that regulate cholesterol homeostasis and dissecting the roles of oncogenic mutations in several metabolic genes including isocitrate dehydrogenase (IDH), fumarate hydratase (FH) and succinate dehydrogenase (SDH).

Publications

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