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Jane Yu, PhD

Instructor, Department of Medicine, Harvard Medical School

Instructor, Medicine, Brigham And Women's Hospital

Contact Info

Jane Yu
Brigham and Women's Hospital
One Blackfan Street

Boston, MA, 02115
Phone: 617-355-9018


Not Available.

DF/HCC Program Affiliation

Angiogenesis, Invasion and Metastasis

Research Abstract

At the BWH, I am focused on the establishment and characterization of the primary cell cultures derived from angiomyolipoma and LAM, investigation of the role of estrogen and anti-estrogen agents in stimulating LAM-associated angiomyolipoma cell growth and signaling pathways, identification of molecular and metabolic signatures associated with estrogen-promoted metabolic alteration and survival of tuberin-deficient cells, and development of animal models of LAM to test the efficacy of FDA-approved drugs. My long-term research goal is to study mechanisms through which tuberin and hamartin regulate estrogen-mediated survival and metastatic phenotypes, and develops estrogen-focused targeted therapeutic strategies for LAM.


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