Jane Yu, PhD
Instructor, Department of Medicine, Harvard Medical School
Instructor, Medicine, Brigham And Women's Hospital
DF/HCC Program AffiliationAngiogenesis, Invasion and Metastasis
At the BWH, I am focused on the establishment and characterization of the primary cell cultures derived from angiomyolipoma and LAM, investigation of the role of estrogen and anti-estrogen agents in stimulating LAM-associated angiomyolipoma cell growth and signaling pathways, identification of molecular and metabolic signatures associated with estrogen-promoted metabolic alteration and survival of tuberin-deficient cells, and development of animal models of LAM to test the efficacy of FDA-approved drugs. My long-term research goal is to study mechanisms through which tuberin and hamartin regulate estrogen-mediated survival and metastatic phenotypes, and develops estrogen-focused targeted therapeutic strategies for LAM.
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